FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312113818> ?p ?o ?g. }

• W4312113818 endingPage "258" @default.
• W4312113818 startingPage "245" @default.
• W4312113818 abstract "Abstract DM9 domain containing protein (DM9CP) is a family of newly identified recognition receptors exiting in most organisms except plants and mammals. In the current study, to our knowledge, a novel DM9CP-5 (CgDM9CP-5) with two tandem DM9 repeats and high expression level in gill was identified from the Pacific oyster, Crassostrea gigas. The deduced amino acid sequence of CgDM9CP-5 shared 62.1% identity with CgDM9CP-1 from C. gigas, and 47.8% identity with OeFAMeT from Ostrea edulis. The recombinant CgDM9CP-5 (rCgDM9CP-5) was able to bind d-mannose, LPS, peptidoglycan, and polyinosinic-polycytidylic acid, as well as fungi Pichia pastoris, Gram-negative bacteria Escherichia coli and Vibrio splendidus, and Gram-positive bacteria Staphylococcus aureus. The mRNA transcript of CgDM9CP-5 was highly expressed in gill, and its protein was mainly distributed in gill mucus. After the stimulations with V. splendidus and mannose, mRNA expression of CgDM9CP-5 in oyster gill was significantly upregulated and reached the peak level at 6 and 24 h, which was 13.58-fold (p &lt; 0.05) and 14.01-fold (p &lt; 0.05) of that in the control group, respectively. CgDM9CP-5 was able to bind CgIntegrin both in vivo and in vitro. After CgDM9CP-5 or CgIntegrin was knocked down by RNA interference, the phosphorylation levels of JNK and P38 in the MAPK pathway decreased, and the expression levels of CgIL-17s (CgIL-17-3, -4, -5, and -6), Cg-Defh1, Cg-Defh2, and CgMolluscidin were significantly downregulated. These results suggested that there was a pathway of DM9CP-5-Integrin-MAPK mediated by CgDM9CP-5 to regulate the release of proinflammatory factors and defensins in C. gigas." @default.
• W4312113818 created "2023-01-04" @default.
• W4312113818 creator A5000093771 @default.
• W4312113818 creator A5017240402 @default.
• W4312113818 creator A5018073672 @default.
• W4312113818 creator A5026227737 @default.
• W4312113818 creator A5028930141 @default.
• W4312113818 creator A5040054751 @default.
• W4312113818 creator A5053780153 @default.
• W4312113818 creator A5072322924 @default.
• W4312113818 creator A5087911287 @default.
• W4312113818 date "2023-02-01" @default.
• W4312113818 modified "2023-10-10" @default.
• W4312113818 title "<i>Cg</i>DM9CP-5-Integrin-MAPK Pathway Regulates the Production of <i>Cg</i>IL-17s and <i>Cg</i>defensins in the Pacific Oyster, <i>Crassostrea gigas</i>" @default.
• W4312113818 cites W1092112813 @default.
• W4312113818 cites W1539600225 @default.
• W4312113818 cites W1964435410 @default.
• W4312113818 cites W1989343286 @default.
• W4312113818 cites W1996644651 @default.
• W4312113818 cites W2012073892 @default.
• W4312113818 cites W2015376237 @default.
• W4312113818 cites W2018211058 @default.
• W4312113818 cites W2022359905 @default.
• W4312113818 cites W2022665330 @default.
• W4312113818 cites W2026345779 @default.
• W4312113818 cites W2032229966 @default.
• W4312113818 cites W2042433863 @default.
• W4312113818 cites W2047688038 @default.
• W4312113818 cites W2069875470 @default.
• W4312113818 cites W2085188889 @default.
• W4312113818 cites W2094499798 @default.
• W4312113818 cites W2107277218 @default.
• W4312113818 cites W2114737175 @default.
• W4312113818 cites W2118169890 @default.
• W4312113818 cites W2125297253 @default.
• W4312113818 cites W2125513228 @default.
• W4312113818 cites W2139223335 @default.
• W4312113818 cites W2139592842 @default.
• W4312113818 cites W2149358967 @default.
• W4312113818 cites W2151034762 @default.
• W4312113818 cites W2161589290 @default.
• W4312113818 cites W2163996557 @default.
• W4312113818 cites W2188211649 @default.
• W4312113818 cites W2192080449 @default.
• W4312113818 cites W2218732210 @default.
• W4312113818 cites W2290042189 @default.
• W4312113818 cites W2402708657 @default.
• W4312113818 cites W2409685932 @default.
• W4312113818 cites W2474681053 @default.
• W4312113818 cites W2561395983 @default.
• W4312113818 cites W2562302955 @default.
• W4312113818 cites W2563306892 @default.
• W4312113818 cites W2620889645 @default.
• W4312113818 cites W2753509609 @default.
• W4312113818 cites W2769507775 @default.
• W4312113818 cites W2790190757 @default.
• W4312113818 cites W2792648303 @default.
• W4312113818 cites W2799524357 @default.
• W4312113818 cites W2887504899 @default.
• W4312113818 cites W2894768040 @default.
• W4312113818 cites W2909095167 @default.
• W4312113818 cites W2971730418 @default.
• W4312113818 cites W2985168738 @default.
• W4312113818 cites W3000427586 @default.
• W4312113818 cites W3002355165 @default.
• W4312113818 cites W3003806929 @default.
• W4312113818 cites W3044322347 @default.
• W4312113818 cites W3106548711 @default.
• W4312113818 cites W3132350314 @default.
• W4312113818 cites W3157521588 @default.
• W4312113818 cites W873995106 @default.
• W4312113818 doi "https://doi.org/10.4049/jimmunol.2200016" @default.
• W4312113818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36548464" @default.
• W4312113818 hasPublicationYear "2023" @default.
• W4312113818 type Work @default.
• W4312113818 citedByCount "1" @default.
• W4312113818 crossrefType "journal-article" @default.
• W4312113818 hasAuthorship W4312113818A5000093771 @default.
• W4312113818 hasAuthorship W4312113818A5017240402 @default.
• W4312113818 hasAuthorship W4312113818A5018073672 @default.
• W4312113818 hasAuthorship W4312113818A5026227737 @default.
• W4312113818 hasAuthorship W4312113818A5028930141 @default.
• W4312113818 hasAuthorship W4312113818A5040054751 @default.
• W4312113818 hasAuthorship W4312113818A5053780153 @default.
• W4312113818 hasAuthorship W4312113818A5072322924 @default.
• W4312113818 hasAuthorship W4312113818A5087911287 @default.
• W4312113818 hasBestOaLocation W43121138181 @default.
• W4312113818 hasConcept C104317684 @default.
• W4312113818 hasConcept C153911025 @default.
• W4312113818 hasConcept C2776364969 @default.
• W4312113818 hasConcept C2776634448 @default.
• W4312113818 hasConcept C2776845067 @default.
• W4312113818 hasConcept C2781047198 @default.
• W4312113818 hasConcept C2781372317 @default.
• W4312113818 hasConcept C40767141 @default.
• W4312113818 hasConcept C505870484 @default.
• W4312113818 hasConcept C55493867 @default.
• W4312113818 hasConcept C86803240 @default.

• next