FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312114077> ?p ?o ?g. }

• W4312114077 endingPage "1555" @default.
• W4312114077 startingPage "1541" @default.
• W4312114077 abstract "The high glycolytic activity of cancer cells leads to lactic acidosis (LA) in the tumor microenvironment. LA is not merely a consequence of metabolic activities but also has functional roles in metabolic reprogramming and cancer progression. Cholangiocarcinoma (CCA) cells exhibit a high dependency on glycolysis for survival and growth, but the specific effects of LA on cellular characteristics remain unknown. Here, we demonstrate that long-term LA (LLA) reprograms the metabolic phenotype of CCA cells from glycolytic to oxidative and enhances their migratory activity. In CCA cell culture, short-term LA (24 h) showed a growth inhibitory effect, while extended LA exposure for more than 2 weeks (LLA) led to enhanced cell motility. Coincidentally, LLA enhanced the respiratory capacity with an increase in mitochondrial mass. Inhibition of mitochondrial function abolished LLA-induced cell motility, suggesting that metabolic remodeling affects the phenotypic outcomes. RNA-sequencing analysis revealed that LLA upregulated genes associated with cell migration and epithelial-mesenchymal transition (EMT), including thrombospondin-1 (THBS1), which encodes a pro-EMT-secreted protein. Inhibition of THBS1 resulted in the suppression of both LLA-induced cell motility and respiratory capacity. Moreover, high THBS1 expression was associated with poor survival in patients with CCA. Collectively, our study suggests that the increased expression of THBS1 by LLA promotes phenotypic alterations, leading to CCA progression." @default.
• W4312114077 created "2023-01-04" @default.
• W4312114077 creator A5001118089 @default.
• W4312114077 creator A5003446927 @default.
• W4312114077 creator A5003764046 @default.
• W4312114077 creator A5027417160 @default.
• W4312114077 creator A5034438931 @default.
• W4312114077 creator A5036405854 @default.
• W4312114077 creator A5063785822 @default.
• W4312114077 creator A5071692471 @default.
• W4312114077 creator A5085285766 @default.
• W4312114077 date "2023-01-28" @default.
• W4312114077 modified "2023-10-14" @default.
• W4312114077 title "Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin‐1" @default.
• W4312114077 cites W1571584684 @default.
• W4312114077 cites W1970613354 @default.
• W4312114077 cites W1972304747 @default.
• W4312114077 cites W1984150991 @default.
• W4312114077 cites W1985159629 @default.
• W4312114077 cites W2002750345 @default.
• W4312114077 cites W2011185005 @default.
• W4312114077 cites W2020191309 @default.
• W4312114077 cites W2050417412 @default.
• W4312114077 cites W2089791673 @default.
• W4312114077 cites W2117419186 @default.
• W4312114077 cites W2169456326 @default.
• W4312114077 cites W2172295116 @default.
• W4312114077 cites W2227139775 @default.
• W4312114077 cites W2234115940 @default.
• W4312114077 cites W2347019354 @default.
• W4312114077 cites W2395626624 @default.
• W4312114077 cites W2538171015 @default.
• W4312114077 cites W2582450858 @default.
• W4312114077 cites W2592717780 @default.
• W4312114077 cites W2755677304 @default.
• W4312114077 cites W2897133708 @default.
• W4312114077 cites W2899950670 @default.
• W4312114077 cites W2901951820 @default.
• W4312114077 cites W2913164436 @default.
• W4312114077 cites W2920478943 @default.
• W4312114077 cites W2921749385 @default.
• W4312114077 cites W2922231125 @default.
• W4312114077 cites W2922778385 @default.
• W4312114077 cites W2980464418 @default.
• W4312114077 cites W2984799663 @default.
• W4312114077 cites W2996177965 @default.
• W4312114077 cites W3001738994 @default.
• W4312114077 cites W3027242253 @default.
• W4312114077 cites W3081151581 @default.
• W4312114077 cites W3081332467 @default.
• W4312114077 cites W3083127474 @default.
• W4312114077 cites W3120302588 @default.
• W4312114077 cites W3158005688 @default.
• W4312114077 cites W3161366404 @default.
• W4312114077 cites W3185873921 @default.
• W4312114077 cites W4211248913 @default.
• W4312114077 cites W4280606356 @default.
• W4312114077 cites W4280616882 @default.
• W4312114077 cites W4295425529 @default.
• W4312114077 cites W4312114077 @default.
• W4312114077 doi "https://doi.org/10.1111/cas.15699" @default.
• W4312114077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36562400" @default.
• W4312114077 hasPublicationYear "2023" @default.
• W4312114077 type Work @default.
• W4312114077 citedByCount "1" @default.
• W4312114077 countsByYear W43121140772023 @default.
• W4312114077 crossrefType "journal-article" @default.
• W4312114077 hasAuthorship W4312114077A5001118089 @default.
• W4312114077 hasAuthorship W4312114077A5003446927 @default.
• W4312114077 hasAuthorship W4312114077A5003764046 @default.
• W4312114077 hasAuthorship W4312114077A5027417160 @default.
• W4312114077 hasAuthorship W4312114077A5034438931 @default.
• W4312114077 hasAuthorship W4312114077A5036405854 @default.
• W4312114077 hasAuthorship W4312114077A5063785822 @default.
• W4312114077 hasAuthorship W4312114077A5071692471 @default.
• W4312114077 hasAuthorship W4312114077A5085285766 @default.
• W4312114077 hasBestOaLocation W43121140771 @default.
• W4312114077 hasConcept C104317684 @default.
• W4312114077 hasConcept C121608353 @default.
• W4312114077 hasConcept C127561419 @default.
• W4312114077 hasConcept C127716648 @default.
• W4312114077 hasConcept C134018914 @default.
• W4312114077 hasConcept C20251656 @default.
• W4312114077 hasConcept C2778877718 @default.
• W4312114077 hasConcept C2779306644 @default.
• W4312114077 hasConcept C2780323712 @default.
• W4312114077 hasConcept C2780394083 @default.
• W4312114077 hasConcept C502942594 @default.
• W4312114077 hasConcept C54355233 @default.
• W4312114077 hasConcept C55493867 @default.
• W4312114077 hasConcept C55885012 @default.
• W4312114077 hasConcept C57600042 @default.
• W4312114077 hasConcept C58207958 @default.
• W4312114077 hasConcept C62112901 @default.
• W4312114077 hasConcept C62231903 @default.
• W4312114077 hasConcept C86803240 @default.
• W4312114077 hasConcept C95444343 @default.
• W4312114077 hasConcept C96232424 @default.

• next