FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312114295> ?p ?o ?g. }

• W4312114295 abstract "There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc comparison of samples from the DS-Cav1 [prefusion (pre-F)] and MEDI7510 [postfusion (post-F)] vaccine clinical trials. We compared the magnitude and quality of the serological and B cell responses across time points and vaccines. We measured RSV A and B neutralization, F-binding immunoglobulin G titers, and competition assays at week 0 (before vaccination) and week 4 (after vaccination) to evaluate antibody specificity and potency. To compare B cell specificity and activation, we used pre-F and post-F probes in tandem with a 17-color immunophenotyping flow cytometry panel at week 0 (before vaccination) and week 1 (after vaccination). Our data demonstrate that both DS-Cav1 and MEDI7510 vaccination robustly elicit F-specific antibodies and B cells, but DS-Cav1 elicited antibodies that more potently neutralized both RSV A and B. The superior potency was mediated by antibodies that bind antigenic sites on the apex of pre-F that are not present on post-F. In the memory (CD27+) B cell compartment, vaccination with DS-Cav1 or MEDI7510 elicited B cells with different epitope specificities. B cells preferentially binding the pre-F probe were activated in DS-Cav1-vaccinated participants but not in MEDI7510-vaccinated participants. Our findings emphasize the importance of using pre-F as an immunogen in humans because of its deterministic role in eliciting highly potent neutralizing antibodies and memory B cells." @default.
• W4312114295 created "2023-01-04" @default.
• W4312114295 creator A5009078261 @default.
• W4312114295 creator A5009813178 @default.
• W4312114295 creator A5016041349 @default.
• W4312114295 creator A5018055017 @default.
• W4312114295 creator A5021608465 @default.
• W4312114295 creator A5038903505 @default.
• W4312114295 creator A5041826497 @default.
• W4312114295 creator A5047665192 @default.
• W4312114295 creator A5063537600 @default.
• W4312114295 creator A5075202938 @default.
• W4312114295 creator A5081967303 @default.
• W4312114295 creator A5091048034 @default.
• W4312114295 date "2022-12-21" @default.
• W4312114295 modified "2023-10-03" @default.
• W4312114295 title "A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine" @default.
• W4312114295 cites W103182913 @default.
• W4312114295 cites W1508193774 @default.
• W4312114295 cites W2003941826 @default.
• W4312114295 cites W2066937401 @default.
• W4312114295 cites W2111890970 @default.
• W4312114295 cites W2111999914 @default.
• W4312114295 cites W2115345608 @default.
• W4312114295 cites W2120123267 @default.
• W4312114295 cites W2123817481 @default.
• W4312114295 cites W2126114330 @default.
• W4312114295 cites W2160875353 @default.
• W4312114295 cites W2270869679 @default.
• W4312114295 cites W2318832328 @default.
• W4312114295 cites W2340198326 @default.
• W4312114295 cites W2476253301 @default.
• W4312114295 cites W2497835434 @default.
• W4312114295 cites W2510979876 @default.
• W4312114295 cites W2533150511 @default.
• W4312114295 cites W2563378637 @default.
• W4312114295 cites W2580955103 @default.
• W4312114295 cites W2582217477 @default.
• W4312114295 cites W2619147606 @default.
• W4312114295 cites W2724742338 @default.
• W4312114295 cites W2727509207 @default.
• W4312114295 cites W2757615417 @default.
• W4312114295 cites W2759073829 @default.
• W4312114295 cites W2765110787 @default.
• W4312114295 cites W2766966717 @default.
• W4312114295 cites W2784885284 @default.
• W4312114295 cites W2808415597 @default.
• W4312114295 cites W2916872624 @default.
• W4312114295 cites W2921286122 @default.
• W4312114295 cites W2935814674 @default.
• W4312114295 cites W2938362339 @default.
• W4312114295 cites W2959793769 @default.
• W4312114295 cites W2964965456 @default.
• W4312114295 cites W2972212509 @default.
• W4312114295 cites W2972594574 @default.
• W4312114295 cites W2974261317 @default.
• W4312114295 cites W3031953402 @default.
• W4312114295 cites W3045880340 @default.
• W4312114295 cites W3046024889 @default.
• W4312114295 cites W3150939132 @default.
• W4312114295 cites W3154936721 @default.
• W4312114295 cites W3170978527 @default.
• W4312114295 cites W3172576497 @default.
• W4312114295 cites W3216615855 @default.
• W4312114295 cites W4200581680 @default.
• W4312114295 cites W4211207275 @default.
• W4312114295 cites W4220764073 @default.
• W4312114295 cites W4283275905 @default.
• W4312114295 cites W4297452555 @default.
• W4312114295 cites W950646933 @default.
• W4312114295 doi "https://doi.org/10.1126/scitranslmed.ade0424" @default.
• W4312114295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36542692" @default.
• W4312114295 hasPublicationYear "2022" @default.
• W4312114295 type Work @default.
• W4312114295 citedByCount "7" @default.
• W4312114295 countsByYear W43121142952022 @default.
• W4312114295 countsByYear W43121142952023 @default.
• W4312114295 crossrefType "journal-article" @default.
• W4312114295 hasAuthorship W4312114295A5009078261 @default.
• W4312114295 hasAuthorship W4312114295A5009813178 @default.
• W4312114295 hasAuthorship W4312114295A5016041349 @default.
• W4312114295 hasAuthorship W4312114295A5018055017 @default.
• W4312114295 hasAuthorship W4312114295A5021608465 @default.
• W4312114295 hasAuthorship W4312114295A5038903505 @default.
• W4312114295 hasAuthorship W4312114295A5041826497 @default.
• W4312114295 hasAuthorship W4312114295A5047665192 @default.
• W4312114295 hasAuthorship W4312114295A5063537600 @default.
• W4312114295 hasAuthorship W4312114295A5075202938 @default.
• W4312114295 hasAuthorship W4312114295A5081967303 @default.
• W4312114295 hasAuthorship W4312114295A5091048034 @default.
• W4312114295 hasConcept C159047783 @default.
• W4312114295 hasConcept C159654299 @default.
• W4312114295 hasConcept C195616568 @default.
• W4312114295 hasConcept C202751555 @default.
• W4312114295 hasConcept C203014093 @default.
• W4312114295 hasConcept C22070199 @default.
• W4312114295 hasConcept C2778453870 @default.
• W4312114295 hasConcept C2779261636 @default.
• W4312114295 hasConcept C2779359726 @default.
• W4312114295 hasConcept C2779909307 @default.

• next