Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312115375> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4312115375 endingPage "435" @default.
- W4312115375 startingPage "427" @default.
- W4312115375 abstract "In the OPTIMUM trial in patients with relapsing MS, treatment differences in annualized relapse rate (ARR, 0.088) and change in fatigue at week 108 (3.57 points, measured using the Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis, symptom domain (FSIQ-RMS-S)) favored ponesimod over teriflunomide. However, the importance of the fatigue outcome to patients was unclear.To assess the importance of the OPTIMUM FSIQ-RMS-S results using data from an MS discrete choice experiment (DCE).The DCE included components to correlate levels of physical and cognitive fatigue with FSIQ-RMS-S scores. Changes in relapses/year and time to MS progression equivalent to the treatment difference in fatigue in OPTIMUM were determined for similar fatigue levels as mean baseline fatigue in OPTIMUM.DCE participants would accept 0.06 more relapses/year or a 0.15-0.17 year decrease in time to MS progression for a 3.57-point difference in physical fatigue on the FSIQ-RMS-S. To improve cognitive fatigue by 3.57-points on the FSIQ-RMS-S, DCE participants would accept 0.09-0.10 more relapses/year or a 0.24-0.28 year decrease in time to MS progression.MS patients would accept 0.06 more relapses/year to change their fatigue by a similar magnitude as the between-treatment difference observed in the OPTIMUM trial." @default.
- W4312115375 created "2023-01-04" @default.
- W4312115375 creator A5004963929 @default.
- W4312115375 creator A5006987507 @default.
- W4312115375 creator A5007913206 @default.
- W4312115375 creator A5018311040 @default.
- W4312115375 creator A5029734617 @default.
- W4312115375 creator A5037125817 @default.
- W4312115375 creator A5069099491 @default.
- W4312115375 creator A5090856144 @default.
- W4312115375 creator A5090931498 @default.
- W4312115375 date "2022-12-22" @default.
- W4312115375 modified "2023-09-25" @default.
- W4312115375 title "The relevance of fatigue to relapse rate in multiple sclerosis: Applying patient preference data to the OPTIMUM trial" @default.
- W4312115375 cites W185235087 @default.
- W4312115375 cites W2043591841 @default.
- W4312115375 cites W2106020444 @default.
- W4312115375 cites W2118735809 @default.
- W4312115375 cites W2129967156 @default.
- W4312115375 cites W2133329597 @default.
- W4312115375 cites W2151340435 @default.
- W4312115375 cites W2176783409 @default.
- W4312115375 cites W2279770648 @default.
- W4312115375 cites W2302182518 @default.
- W4312115375 cites W24020054 @default.
- W4312115375 cites W2916673835 @default.
- W4312115375 cites W2920839124 @default.
- W4312115375 cites W3149798718 @default.
- W4312115375 cites W4250968058 @default.
- W4312115375 cites W4317733172 @default.
- W4312115375 doi "https://doi.org/10.1177/13524585221140270" @default.
- W4312115375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36550636" @default.
- W4312115375 hasPublicationYear "2022" @default.
- W4312115375 type Work @default.
- W4312115375 citedByCount "1" @default.
- W4312115375 countsByYear W43121153752023 @default.
- W4312115375 crossrefType "journal-article" @default.
- W4312115375 hasAuthorship W4312115375A5004963929 @default.
- W4312115375 hasAuthorship W4312115375A5006987507 @default.
- W4312115375 hasAuthorship W4312115375A5007913206 @default.
- W4312115375 hasAuthorship W4312115375A5018311040 @default.
- W4312115375 hasAuthorship W4312115375A5029734617 @default.
- W4312115375 hasAuthorship W4312115375A5037125817 @default.
- W4312115375 hasAuthorship W4312115375A5069099491 @default.
- W4312115375 hasAuthorship W4312115375A5090856144 @default.
- W4312115375 hasAuthorship W4312115375A5090931498 @default.
- W4312115375 hasBestOaLocation W43121153751 @default.
- W4312115375 hasConcept C118552586 @default.
- W4312115375 hasConcept C126322002 @default.
- W4312115375 hasConcept C169900460 @default.
- W4312115375 hasConcept C1862650 @default.
- W4312115375 hasConcept C2780640218 @default.
- W4312115375 hasConcept C71924100 @default.
- W4312115375 hasConceptScore W4312115375C118552586 @default.
- W4312115375 hasConceptScore W4312115375C126322002 @default.
- W4312115375 hasConceptScore W4312115375C169900460 @default.
- W4312115375 hasConceptScore W4312115375C1862650 @default.
- W4312115375 hasConceptScore W4312115375C2780640218 @default.
- W4312115375 hasConceptScore W4312115375C71924100 @default.
- W4312115375 hasFunder F4320338282 @default.
- W4312115375 hasIssue "3" @default.
- W4312115375 hasLocation W43121153751 @default.
- W4312115375 hasLocation W43121153752 @default.
- W4312115375 hasLocation W43121153753 @default.
- W4312115375 hasOpenAccess W4312115375 @default.
- W4312115375 hasPrimaryLocation W43121153751 @default.
- W4312115375 hasRelatedWork W2022521083 @default.
- W4312115375 hasRelatedWork W2052767160 @default.
- W4312115375 hasRelatedWork W2081809205 @default.
- W4312115375 hasRelatedWork W2154791388 @default.
- W4312115375 hasRelatedWork W2418985235 @default.
- W4312115375 hasRelatedWork W2617222556 @default.
- W4312115375 hasRelatedWork W2744513970 @default.
- W4312115375 hasRelatedWork W2808245748 @default.
- W4312115375 hasRelatedWork W68739345 @default.
- W4312115375 hasRelatedWork W2112863149 @default.
- W4312115375 hasVolume "29" @default.
- W4312115375 isParatext "false" @default.
- W4312115375 isRetracted "false" @default.
- W4312115375 workType "article" @default.