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• W4312116004 abstract "Epidermal growth factor receptor (EGFR) exon 20 insertion mutations (ex20ins) are uncommon in non-small cell lung cancer (NSCLC). These mutations are generally resistant to first-generation EGFR tyrosine kinase inhibitors, unlike common EGFR mutations, including exon 19 deletions or exon 21 L858R point mutation. The development of effective targeted therapies for NSCLC harboring EGFR ex20ins has been eagerly anticipated over the years. Recently, the therapeutic landscape of this subgroup of EGFR-mutant NSCLC patients has rapidly evolved due to the emergence of new drugs. In 2021, several novel agents, such as amivantamab and mobocertinib, have been approved by the US Food and Drug Administration for patients with advanced platinum-resistant NSCLC harboring EGFR ex20ins. In this review, we mainly focus on emerging therapies targeting NSCLC with EGFR ex20ins, as well as important ongoing clinical trials.Searches were conducted in PubMed and supplemented with recent conference proceedings in November 30th, 2021.Several novel emerging therapies showed favorable safety profile and promising anti-tumor activity in NSCLC patients with EGFR ex20ins in recent several clinical trials.There is still room for improvement in the treatment results of NSCLC harboring EGFR ex20ins. Future research should focus on the molecular heterogeneity in the size and location of distinct EGFR ex20ins, the mechanisms of acquired resistance to novel EGFR inhibitors, effective treatment that have good central nervous system penetrance, and the potential role of combination strategy." @default.
• W4312116004 created "2023-01-04" @default.
• W4312116004 creator A5029393521 @default.
• W4312116004 creator A5030345379 @default.
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• W4312116004 date "2022-12-01" @default.
• W4312116004 modified "2023-09-26" @default.
• W4312116004 title "Emerging therapies for non-small cell lung cancer harboring EGFR exon 20 insertion mutations: narrative review" @default.
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• W4312116004 doi "https://doi.org/10.21037/atm-2022-56" @default.
• W4312116004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36618815" @default.
• W4312116004 hasPublicationYear "2022" @default.
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