FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312118630> ?p ?o ?g. }

• W4312118630 endingPage "2421" @default.
• W4312118630 startingPage "2404" @default.
• W4312118630 abstract "The HSC70/HSP70 family of heat shock proteins are evolutionarily conserved chaperones involved in protein folding, protein transport, and RNA binding. Arabidopsis HSC70 chaperones are thought to act as housekeeping chaperones and as such are involved in many growth-related pathways. Whether Arabidopsis HSC70 binds RNA and whether this interaction is functional has remained an open question. We provide evidence that the HSC70.1 chaperone binds its own mRNA via its C-terminal short variable region (SVR) and inhibits its own translation. The SVR encoding mRNA region is necessary for HSC70.1 transcript mobility to distant tissues and that HSC70.1 transcript and not protein mobility is required to rescue root growth and flowering time of hsc70 mutants. We propose that this negative protein-transcript feedback loop may establish an on-demand chaperone pool that allows for a rapid response to stress. In summary, our data suggest that the Arabidopsis HSC70.1 chaperone can form a complex with its own transcript to regulate its translation and that both protein and transcript can act in a noncell-autonomous manner, potentially maintaining chaperone homeostasis between tissues." @default.
• W4312118630 created "2023-01-04" @default.
• W4312118630 creator A5007553500 @default.
• W4312118630 creator A5023549221 @default.
• W4312118630 creator A5040270973 @default.
• W4312118630 creator A5056799368 @default.
• W4312118630 creator A5071294186 @default.
• W4312118630 creator A5071391432 @default.
• W4312118630 creator A5072657490 @default.
• W4312118630 creator A5083376625 @default.
• W4312118630 creator A5083955309 @default.
• W4312118630 date "2023-01-22" @default.
• W4312118630 modified "2023-09-25" @default.
• W4312118630 title "Noncell‐autonomous <scp>HSC70</scp>.1 chaperone displays homeostatic feedback regulation by binding its own <scp>mRNA</scp>" @default.
• W4312118630 cites W1563197929 @default.
• W4312118630 cites W160183570 @default.
• W4312118630 cites W1963550266 @default.
• W4312118630 cites W1992909271 @default.
• W4312118630 cites W1993154139 @default.
• W4312118630 cites W1993251184 @default.
• W4312118630 cites W2003013739 @default.
• W4312118630 cites W2005459694 @default.
• W4312118630 cites W2010476110 @default.
• W4312118630 cites W2013896542 @default.
• W4312118630 cites W2023692919 @default.
• W4312118630 cites W2025763720 @default.
• W4312118630 cites W2029706883 @default.
• W4312118630 cites W2038254496 @default.
• W4312118630 cites W2055498718 @default.
• W4312118630 cites W2060944544 @default.
• W4312118630 cites W2061014998 @default.
• W4312118630 cites W2071113845 @default.
• W4312118630 cites W2076510291 @default.
• W4312118630 cites W2078021348 @default.
• W4312118630 cites W2083116972 @default.
• W4312118630 cites W2084285497 @default.
• W4312118630 cites W2086561953 @default.
• W4312118630 cites W2089874769 @default.
• W4312118630 cites W2098115340 @default.
• W4312118630 cites W2103301028 @default.
• W4312118630 cites W2107330252 @default.
• W4312118630 cites W2108158441 @default.
• W4312118630 cites W2109936231 @default.
• W4312118630 cites W2116907098 @default.
• W4312118630 cites W2129506203 @default.
• W4312118630 cites W2140347764 @default.
• W4312118630 cites W2140671379 @default.
• W4312118630 cites W2141429272 @default.
• W4312118630 cites W2152076750 @default.
• W4312118630 cites W2157236728 @default.
• W4312118630 cites W2157843092 @default.
• W4312118630 cites W2167754439 @default.
• W4312118630 cites W2169139012 @default.
• W4312118630 cites W2320443349 @default.
• W4312118630 cites W2329462941 @default.
• W4312118630 cites W2331699993 @default.
• W4312118630 cites W2418701854 @default.
• W4312118630 cites W2462627705 @default.
• W4312118630 cites W2509466948 @default.
• W4312118630 cites W2559861026 @default.
• W4312118630 cites W2562454443 @default.
• W4312118630 cites W2734183401 @default.
• W4312118630 cites W2774785892 @default.
• W4312118630 cites W2785329615 @default.
• W4312118630 cites W2793341721 @default.
• W4312118630 cites W2799790370 @default.
• W4312118630 cites W2963726320 @default.
• W4312118630 cites W3013110774 @default.
• W4312118630 cites W3123209109 @default.
• W4312118630 cites W3165316389 @default.
• W4312118630 cites W3215204257 @default.
• W4312118630 cites W4206228290 @default.
• W4312118630 cites W4243642973 @default.
• W4312118630 cites W4376043815 @default.
• W4312118630 doi "https://doi.org/10.1111/nph.18703" @default.
• W4312118630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36564968" @default.
• W4312118630 hasPublicationYear "2023" @default.
• W4312118630 type Work @default.
• W4312118630 citedByCount "1" @default.
• W4312118630 countsByYear W43121186302023 @default.
• W4312118630 crossrefType "journal-article" @default.
• W4312118630 hasAuthorship W4312118630A5007553500 @default.
• W4312118630 hasAuthorship W4312118630A5023549221 @default.
• W4312118630 hasAuthorship W4312118630A5040270973 @default.
• W4312118630 hasAuthorship W4312118630A5056799368 @default.
• W4312118630 hasAuthorship W4312118630A5071294186 @default.
• W4312118630 hasAuthorship W4312118630A5071391432 @default.
• W4312118630 hasAuthorship W4312118630A5072657490 @default.
• W4312118630 hasAuthorship W4312118630A5083376625 @default.
• W4312118630 hasAuthorship W4312118630A5083955309 @default.
• W4312118630 hasBestOaLocation W43121186301 @default.
• W4312118630 hasConcept C104317684 @default.
• W4312118630 hasConcept C105580179 @default.
• W4312118630 hasConcept C142724271 @default.
• W4312118630 hasConcept C143065580 @default.
• W4312118630 hasConcept C205260736 @default.
• W4312118630 hasConcept C2775962898 @default.
• W4312118630 hasConcept C2779491563 @default.

• next