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• W4312125691 endingPage "2040" @default.
• W4312125691 startingPage "2040" @default.
• W4312125691 abstract "In recent years, great advances have been made in the field of collection, storage, and analysis of biological samples. Large collections of samples, biobanks, have been established in many countries. Biobanks typically collect large amounts of biological samples and associated clinical information; the largest collections include over a million samples. In this review, we summarize the main directions in which biobanks aid medical genetics and genomic research, from providing reference allele frequency information to allowing large-scale cross-ancestry meta-analyses. The largest biobanks greatly vary in the size of the collection, and the amount of available phenotype and genotype data. Nevertheless, all of them are extensively used in genomics, providing a rich resource for genome-wide association analysis, genetic epidemiology, and statistical research into the structure, function, and evolution of the human genome. Recently, multiple research efforts were based on trans-biobank data integration, which increases sample size and allows for the identification of robust genetic associations. We provide prominent examples of such data integration and discuss important caveats which have to be taken into account in trans-biobank research." @default.
• W4312125691 created "2023-01-04" @default.
• W4312125691 creator A5003172251 @default.
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• W4312125691 creator A5055710016 @default.
• W4312125691 creator A5073454012 @default.
• W4312125691 creator A5086194186 @default.
• W4312125691 date "2022-12-09" @default.
• W4312125691 modified "2023-09-26" @default.
• W4312125691 title "Biobanking as a Tool for Genomic Research: From Allele Frequencies to Cross-Ancestry Association Studies" @default.
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