FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312125890> ?p ?o ?g. }

• W4312125890 endingPage "2450" @default.
• W4312125890 startingPage "2450" @default.
• W4312125890 abstract "Background and Aims: Cases of Clostridioides difficile infection have been rising among the pediatric and adolescent population. Fecal microbiota transplantation (FMT) has emerged as an alternative therapy for recurrent C. difficile infection. We aim to perform the first systematic review and meta-analysis investigating the safety and efficacy of fecal microbiota transplantation for C. difficile infection in children and adolescents. Methods: A literature search was performed using variations of the keywords “pediatrics”, “C. difficile infection”, and “fecal microbiota transplantation” in PubMed, EMBASE, CINAHL, Cochrane, and Google Scholar from inception to 30 June 2022. The resulting 575 articles were independently screened by three authors. Fourteen studies that satisfied the eligibility criteria were included in the meta-analysis. Results: The pooled success rate of FMT in the overall cohort was 86% (95% confidence interval: 77–95%; p < 0.001; I2 = 70%). There were 38 serious adverse events in 36 patients with a pooled rate of 2.0% (95% confidence interval: 0.0–3.0%; p = 0.1; I2 = 0.0%) and 47 adverse events in 45 patients with a pooled rate of 15% (95% confidence interval: 5.0–25.0%; p = 0.02; I2 = 54.0%). There was no death associated with FMT. Conclusions: FMT was concluded to be an effective and safe therapy in pediatric and adolescent patients with C. difficile infection. Underlying comorbidities may impede the efficacy. A rigorous screening process of the donors is recommended prior to embarking on FMT. There is no universal and cost-effective way to monitor the long-term outcomes of FMT. While promising, metagenomic sequencing may not be available in settings with limited resources. Robust data from randomized clinical trials is warranted." @default.
• W4312125890 created "2023-01-04" @default.
• W4312125890 creator A5024951589 @default.
• W4312125890 creator A5032190145 @default.
• W4312125890 creator A5032822168 @default.
• W4312125890 creator A5040137543 @default.
• W4312125890 creator A5044543097 @default.
• W4312125890 creator A5062644627 @default.
• W4312125890 creator A5065963619 @default.
• W4312125890 creator A5075417106 @default.
• W4312125890 date "2022-12-12" @default.
• W4312125890 modified "2023-09-25" @default.
• W4312125890 title "Efficacy and Safety of Fecal Microbiota Transplantation in Treatment of Clostridioides difficile Infection among Pediatric Patients: A Systematic Review and Meta-Analysis" @default.
• W4312125890 cites W1572485915 @default.
• W4312125890 cites W1880023267 @default.
• W4312125890 cites W2018054399 @default.
• W4312125890 cites W2029434488 @default.
• W4312125890 cites W2036740 @default.
• W4312125890 cites W2060901588 @default.
• W4312125890 cites W2066885957 @default.
• W4312125890 cites W2087579422 @default.
• W4312125890 cites W2087897706 @default.
• W4312125890 cites W2093043874 @default.
• W4312125890 cites W2123931921 @default.
• W4312125890 cites W2125435699 @default.
• W4312125890 cites W2125538352 @default.
• W4312125890 cites W2164387970 @default.
• W4312125890 cites W2334270143 @default.
• W4312125890 cites W2345368424 @default.
• W4312125890 cites W2563782682 @default.
• W4312125890 cites W2588596701 @default.
• W4312125890 cites W2737619555 @default.
• W4312125890 cites W2746155660 @default.
• W4312125890 cites W2763699940 @default.
• W4312125890 cites W2771202897 @default.
• W4312125890 cites W2791326569 @default.
• W4312125890 cites W2795360200 @default.
• W4312125890 cites W2799972028 @default.
• W4312125890 cites W2802873701 @default.
• W4312125890 cites W2806277561 @default.
• W4312125890 cites W2889246623 @default.
• W4312125890 cites W2897198560 @default.
• W4312125890 cites W2899014430 @default.
• W4312125890 cites W2903974082 @default.
• W4312125890 cites W2906092467 @default.
• W4312125890 cites W2913062716 @default.
• W4312125890 cites W2939833183 @default.
• W4312125890 cites W2945487772 @default.
• W4312125890 cites W2969278590 @default.
• W4312125890 cites W2970983735 @default.
• W4312125890 cites W2979223145 @default.
• W4312125890 cites W2991315310 @default.
• W4312125890 cites W3021033827 @default.
• W4312125890 cites W3024096493 @default.
• W4312125890 cites W3166492279 @default.
• W4312125890 cites W3180554043 @default.
• W4312125890 cites W3213700754 @default.
• W4312125890 cites W3214252150 @default.
• W4312125890 cites W4200529117 @default.
• W4312125890 cites W4226167594 @default.
• W4312125890 cites W4247300726 @default.
• W4312125890 cites W4283360676 @default.
• W4312125890 doi "https://doi.org/10.3390/microorganisms10122450" @default.
• W4312125890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36557703" @default.
• W4312125890 hasPublicationYear "2022" @default.
• W4312125890 type Work @default.
• W4312125890 citedByCount "2" @default.
• W4312125890 countsByYear W43121258902023 @default.
• W4312125890 crossrefType "journal-article" @default.
• W4312125890 hasAuthorship W4312125890A5024951589 @default.
• W4312125890 hasAuthorship W4312125890A5032190145 @default.
• W4312125890 hasAuthorship W4312125890A5032822168 @default.
• W4312125890 hasAuthorship W4312125890A5040137543 @default.
• W4312125890 hasAuthorship W4312125890A5044543097 @default.
• W4312125890 hasAuthorship W4312125890A5062644627 @default.
• W4312125890 hasAuthorship W4312125890A5065963619 @default.
• W4312125890 hasAuthorship W4312125890A5075417106 @default.
• W4312125890 hasBestOaLocation W43121258901 @default.
• W4312125890 hasConcept C126322002 @default.
• W4312125890 hasConcept C137923570 @default.
• W4312125890 hasConcept C177713679 @default.
• W4312125890 hasConcept C197934379 @default.
• W4312125890 hasConcept C2908647359 @default.
• W4312125890 hasConcept C2910067853 @default.
• W4312125890 hasConcept C2911091166 @default.
• W4312125890 hasConcept C2994496256 @default.
• W4312125890 hasConcept C44249647 @default.
• W4312125890 hasConcept C501593827 @default.
• W4312125890 hasConcept C71924100 @default.
• W4312125890 hasConcept C86803240 @default.
• W4312125890 hasConcept C89423630 @default.
• W4312125890 hasConcept C95190672 @default.
• W4312125890 hasConcept C99454951 @default.
• W4312125890 hasConceptScore W4312125890C126322002 @default.
• W4312125890 hasConceptScore W4312125890C137923570 @default.
• W4312125890 hasConceptScore W4312125890C177713679 @default.
• W4312125890 hasConceptScore W4312125890C197934379 @default.
• W4312125890 hasConceptScore W4312125890C2908647359 @default.

• next