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- W4312127270 endingPage "15749" @default.
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- W4312127270 abstract "Globally, there are over half a million new patients with head and neck squamous cell carcinomas (HNSCC) every year. The current therapeutic approaches to HNSCC are surgery and adjuvant radiotherapy. These approaches carry a high incidence of metastasis or recurrence from HNSCC cells' radioresistance. Recent studies have revealed that a combination with radiosensitizers can be used to improve the radioresistance in HNSCC; however, few agents are approved as radiosensitizers. The constitutive activation of phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is a vitally oncogenic type of signaling that promotes tumorigenesis, metastasis, and radiotherapy resistance in HNSCC. Pharmacological targeting of PI3K/AKT/mTOR signaling pathway is considered a promising strategy of radiosensitization in HNSCC. In this review, we summarize the oncogenic significance of PI3K/AKT/mTOR signaling in HNSCC with radiotherapy resistance and highlight the therapeutic potential of small molecule inhibitors against PI3K/AKT/mTOR signaling for the radiosensitization in HNSCC treatment. It provides a mechanistic framework for the development of new drugs for radiosensitization in HNSCC radiotherapy via targeting PI3K/AKT/mTOR signaling pathway." @default.
- W4312127270 created "2023-01-04" @default.
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- W4312127270 date "2022-12-12" @default.
- W4312127270 modified "2023-09-30" @default.
- W4312127270 title "Targeting PI3K/AKT/mTOR Signaling Pathway as a Radiosensitization in Head and Neck Squamous Cell Carcinomas" @default.
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- W4312127270 cites W1972963227 @default.
- W4312127270 cites W1977267072 @default.
- W4312127270 cites W1981989535 @default.
- W4312127270 cites W2003379794 @default.
- W4312127270 cites W2015975538 @default.
- W4312127270 cites W2016869069 @default.
- W4312127270 cites W2031087011 @default.
- W4312127270 cites W2052765315 @default.
- W4312127270 cites W2057370954 @default.
- W4312127270 cites W2067311782 @default.
- W4312127270 cites W2076361273 @default.
- W4312127270 cites W2078353681 @default.
- W4312127270 cites W2094073838 @default.
- W4312127270 cites W2106787323 @default.
- W4312127270 cites W2110443482 @default.
- W4312127270 cites W2119886330 @default.
- W4312127270 cites W2129827034 @default.
- W4312127270 cites W2147353530 @default.
- W4312127270 cites W2150075935 @default.
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- W4312127270 cites W2320712135 @default.
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- W4312127270 doi "https://doi.org/10.3390/ijms232415749" @default.
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