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- W4312127533 endingPage "3205" @default.
- W4312127533 startingPage "3205" @default.
- W4312127533 abstract "Glioblastoma (GBM) is a malignant brain tumor exhibiting rapid and infiltrative growth, with less than 10% of patients surviving over 5 years, despite aggressive and multimodal treatments. The poor prognosis and the lack of effective pharmacological treatments are imputable to a remarkable histological and molecular heterogeneity of GBM, which has led, to date, to the failure of precision oncology and targeted therapies. Identification of molecular biomarkers is a paradigm for comprehensive and tailored treatments; nevertheless, biopsy sampling has proved to be invasive and limited. Radiogenomics is an emerging translational field of research aiming to study the correlation between radiographic signature and underlying gene expression. Although a research field still under development, not yet incorporated into routine clinical practice, it promises to be a useful non-invasive tool for future personalized/adaptive neuro-oncology. This review provides an up-to-date summary of the recent advancements in the use of magnetic resonance imaging (MRI) radiogenomics for the assessment of molecular markers of interest in GBM regarding prognosis and response to treatments, for monitoring recurrence, also providing insights into the potential efficacy of such an approach for survival prognostication. Despite a high sensitivity and specificity in almost all studies, accuracy, reproducibility and clinical value of radiomic features are the Achilles heel of this newborn tool. Looking into the future, investigators’ efforts should be directed towards standardization and a disciplined approach to data collection, algorithms, and statistical analysis." @default.
- W4312127533 created "2023-01-04" @default.
- W4312127533 creator A5016225459 @default.
- W4312127533 creator A5017806075 @default.
- W4312127533 creator A5019091770 @default.
- W4312127533 creator A5028046234 @default.
- W4312127533 creator A5034431443 @default.
- W4312127533 creator A5038899946 @default.
- W4312127533 creator A5063327760 @default.
- W4312127533 creator A5069993810 @default.
- W4312127533 creator A5087336206 @default.
- W4312127533 date "2022-12-09" @default.
- W4312127533 modified "2023-09-25" @default.
- W4312127533 title "Beyond Imaging and Genetic Signature in Glioblastoma: Radiogenomic Holistic Approach in Neuro-Oncology" @default.
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