FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312138052> ?p ?o ?g. }

• W4312138052 abstract "Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but not adult mice, whereas short-term or single inhalations had little effect on cognitive function at both ages. The mechanisms behind these effects, however, are unclear.In the current study, 6- and 60-day-old C57bl mice in the sevoflurane groups were given 3% sevoflurane plus 60% oxygen for three consecutive days, each lasting 2 hours, while those in the control group only got 60% oxygen. The cortex tissues were harvested on the 8th or 62nd day. The tandem mass tags (TMT)pro-based quantitative proteomics combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, Golgi staining, and western blotting analysis were applied to analyze the influences of multiple sevoflurane anesthesia on the cerebral cortex in mice with various ages. The Morris water maze (MWM) test was performed from postnatal day (P)30 to P36 or P84 to P90 after control or multiple sevoflurane treatment. Sevoflurane anesthesia affected spatial learning and memory and diminished dendritic spines primarily in newborn mice, whereas mature animals exhibited no significant alterations.A total of 6247 proteins were measured using the combined quantitative proteomics methods of TMTpro-labeled and LC-MS/MS, 443 of which were associated to the age-dependent neurotoxic mechanism of repeated sevoflurane anesthesia. Furthermore, western blotting research revealed that sevoflurane-induced brain damage in newborn mice may be mediated by increasing the levels of protein expression of CHGB, PTEN, MAP2c, or decreasing the level of SOD2 protein expression.Our findings would help to further the mechanistic study of age-dependent anesthetic neurotoxicity and contribute to seek for effective protection in the developing brain under general anesthesia." @default.
• W4312138052 created "2023-01-04" @default.
• W4312138052 creator A5001630289 @default.
• W4312138052 creator A5002868102 @default.
• W4312138052 creator A5034382078 @default.
• W4312138052 creator A5045810332 @default.
• W4312138052 creator A5054904910 @default.
• W4312138052 creator A5055834733 @default.
• W4312138052 creator A5056500523 @default.
• W4312138052 date "2022-12-13" @default.
• W4312138052 modified "2023-10-15" @default.
• W4312138052 title "Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice" @default.
• W4312138052 cites W2048084175 @default.
• W4312138052 cites W2065368498 @default.
• W4312138052 cites W2093744829 @default.
• W4312138052 cites W2140594985 @default.
• W4312138052 cites W2151368477 @default.
• W4312138052 cites W2158505111 @default.
• W4312138052 cites W2160491292 @default.
• W4312138052 cites W2559910306 @default.
• W4312138052 cites W2599336228 @default.
• W4312138052 cites W2768503224 @default.
• W4312138052 cites W2778158425 @default.
• W4312138052 cites W2807144840 @default.
• W4312138052 cites W2905559566 @default.
• W4312138052 cites W2945178309 @default.
• W4312138052 cites W2988889252 @default.
• W4312138052 cites W2995596053 @default.
• W4312138052 cites W3007127241 @default.
• W4312138052 cites W3012233242 @default.
• W4312138052 cites W3016355638 @default.
• W4312138052 cites W3032037415 @default.
• W4312138052 cites W3042461096 @default.
• W4312138052 cites W3044530738 @default.
• W4312138052 cites W3108616759 @default.
• W4312138052 cites W3113333885 @default.
• W4312138052 cites W3135269463 @default.
• W4312138052 cites W3135535880 @default.
• W4312138052 cites W3154837727 @default.
• W4312138052 cites W3163017087 @default.
• W4312138052 cites W3195674790 @default.
• W4312138052 cites W3205315728 @default.
• W4312138052 cites W3214676397 @default.
• W4312138052 cites W4233598183 @default.
• W4312138052 cites W4284988762 @default.
• W4312138052 doi "https://doi.org/10.3389/fneur.2022.1056947" @default.
• W4312138052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36582614" @default.
• W4312138052 hasPublicationYear "2022" @default.
• W4312138052 type Work @default.
• W4312138052 citedByCount "0" @default.
• W4312138052 crossrefType "journal-article" @default.
• W4312138052 hasAuthorship W4312138052A5001630289 @default.
• W4312138052 hasAuthorship W4312138052A5002868102 @default.
• W4312138052 hasAuthorship W4312138052A5034382078 @default.
• W4312138052 hasAuthorship W4312138052A5045810332 @default.
• W4312138052 hasAuthorship W4312138052A5054904910 @default.
• W4312138052 hasAuthorship W4312138052A5055834733 @default.
• W4312138052 hasAuthorship W4312138052A5056500523 @default.
• W4312138052 hasBestOaLocation W43121380521 @default.
• W4312138052 hasConcept C126322002 @default.
• W4312138052 hasConcept C15744967 @default.
• W4312138052 hasConcept C162356407 @default.
• W4312138052 hasConcept C169760540 @default.
• W4312138052 hasConcept C185592680 @default.
• W4312138052 hasConcept C2775858765 @default.
• W4312138052 hasConcept C2777348757 @default.
• W4312138052 hasConcept C2778162923 @default.
• W4312138052 hasConcept C2781041448 @default.
• W4312138052 hasConcept C2781161787 @default.
• W4312138052 hasConcept C2781453256 @default.
• W4312138052 hasConcept C2985665543 @default.
• W4312138052 hasConcept C31827203 @default.
• W4312138052 hasConcept C42219234 @default.
• W4312138052 hasConcept C43617362 @default.
• W4312138052 hasConcept C44752575 @default.
• W4312138052 hasConcept C71924100 @default.
• W4312138052 hasConcept C98274493 @default.
• W4312138052 hasConceptScore W4312138052C126322002 @default.
• W4312138052 hasConceptScore W4312138052C15744967 @default.
• W4312138052 hasConceptScore W4312138052C162356407 @default.
• W4312138052 hasConceptScore W4312138052C169760540 @default.
• W4312138052 hasConceptScore W4312138052C185592680 @default.
• W4312138052 hasConceptScore W4312138052C2775858765 @default.
• W4312138052 hasConceptScore W4312138052C2777348757 @default.
• W4312138052 hasConceptScore W4312138052C2778162923 @default.
• W4312138052 hasConceptScore W4312138052C2781041448 @default.
• W4312138052 hasConceptScore W4312138052C2781161787 @default.
• W4312138052 hasConceptScore W4312138052C2781453256 @default.
• W4312138052 hasConceptScore W4312138052C2985665543 @default.
• W4312138052 hasConceptScore W4312138052C31827203 @default.
• W4312138052 hasConceptScore W4312138052C42219234 @default.
• W4312138052 hasConceptScore W4312138052C43617362 @default.
• W4312138052 hasConceptScore W4312138052C44752575 @default.
• W4312138052 hasConceptScore W4312138052C71924100 @default.
• W4312138052 hasConceptScore W4312138052C98274493 @default.
• W4312138052 hasFunder F4320321001 @default.
• W4312138052 hasFunder F4320323993 @default.
• W4312138052 hasFunder F4320326709 @default.
• W4312138052 hasFunder F4320336754 @default.
• W4312138052 hasLocation W43121380521 @default.

• next