FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312138110> ?p ?o ?g. }

• W4312138110 abstract "Characteristics of the blood microbiota among adult patients with community-acquired sepsis are poorly understood. Our aim was to analyze the composition of blood microbiota in adult patients with community-acquired sepsis, and correlate changes with non-septic control patients.A prospective observational study was carried out by including adult patients hospitalized for community-acquired sepsis at our center between January and November 2019, by random selection from a pool of eligible patients. Study inclusion was done on the day of sepsis diagnosis. Community acquisition was ascertained by a priori exclusion criteria; sepsis was defined according to the SEPSIS-3 definitions. Each included patient was matched with non-septic control patients by age and gender in a 1:1 fashion enrolled from the general population. Conventional culturing with BacT/ALERT system and 16S rRNA microbiota analysis were performed from blood samples taken in a same time from a patient. Abundance data was analyzed by the CosmosID HUB Microbiome software.Altogether, 13 hospitalized patients were included, 6/13 (46.2%) with sepsis and 7/13 (53.8%) with septic shock at diagnosis. The most prevalent etiopathogen isolated from blood cultures was Escherichia coli, patients mostly had intraabdominal septic source. At day 28, all-cause mortality was 15.4% (2/13). Compared to non-septic control patients, a relative scarcity of Faecalibacterium, Blautia, Coprococcus and Roseburia genera, with an abundance of Enhydrobacter, Pseudomonas and Micrococcus genera was observed among septic patients. Relative differences between septic vs. non-septic patients were more obvious at the phylum level, mainly driven by Firmicutes (25.7% vs. 63.1%; p<0.01) and Proteobacteria (36.9% vs. 16.6%; p<0.01). The alpha diversity, quantified by the Chao1 index showed statistically significant difference between septic vs. non-septic patients (126 ± 51 vs. 66 ± 26; p<0.01). The Bray-Curtis beta diversity, reported by principal coordinate analysis of total hit frequencies, revealed 2 potentially separate clusters among septic vs. non-septic patients.In adult patients with community-acquired sepsis, specific changes in the composition and abundance of blood microbiota could be detected by 16S rRNA metagenome sequencing, compared to non-septic control patients. Traditional blood culture results only partially correlate with microbiota test results." @default.
• W4312138110 created "2023-01-04" @default.
• W4312138110 creator A5017108968 @default.
• W4312138110 creator A5048064519 @default.
• W4312138110 creator A5053751103 @default.
• W4312138110 creator A5054023245 @default.
• W4312138110 creator A5064071267 @default.
• W4312138110 creator A5078964018 @default.
• W4312138110 creator A5081579737 @default.
• W4312138110 creator A5083357248 @default.
• W4312138110 date "2022-12-13" @default.
• W4312138110 modified "2023-10-04" @default.
• W4312138110 title "Composition and changes of blood microbiota in adult patients with community-acquired sepsis: A pilot study from bench to bedside" @default.
• W4312138110 cites W1582966220 @default.
• W4312138110 cites W1960892544 @default.
• W4312138110 cites W2166691283 @default.
• W4312138110 cites W2272721999 @default.
• W4312138110 cites W2280404143 @default.
• W4312138110 cites W2286207478 @default.
• W4312138110 cites W2539186102 @default.
• W4312138110 cites W2791883502 @default.
• W4312138110 cites W2899825231 @default.
• W4312138110 cites W2943903553 @default.
• W4312138110 cites W2952874835 @default.
• W4312138110 cites W2963861815 @default.
• W4312138110 cites W3029420556 @default.
• W4312138110 cites W3111677299 @default.
• W4312138110 cites W3176575342 @default.
• W4312138110 cites W3182034478 @default.
• W4312138110 cites W3183896543 @default.
• W4312138110 cites W3186476404 @default.
• W4312138110 cites W3189612848 @default.
• W4312138110 cites W3210546158 @default.
• W4312138110 cites W4283365059 @default.
• W4312138110 cites W4285742832 @default.
• W4312138110 cites W4288925027 @default.
• W4312138110 cites W4297537339 @default.
• W4312138110 doi "https://doi.org/10.3389/fcimb.2022.1067476" @default.
• W4312138110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36583109" @default.
• W4312138110 hasPublicationYear "2022" @default.
• W4312138110 type Work @default.
• W4312138110 citedByCount "0" @default.
• W4312138110 crossrefType "journal-article" @default.
• W4312138110 hasAuthorship W4312138110A5017108968 @default.
• W4312138110 hasAuthorship W4312138110A5048064519 @default.
• W4312138110 hasAuthorship W4312138110A5053751103 @default.
• W4312138110 hasAuthorship W4312138110A5054023245 @default.
• W4312138110 hasAuthorship W4312138110A5064071267 @default.
• W4312138110 hasAuthorship W4312138110A5078964018 @default.
• W4312138110 hasAuthorship W4312138110A5081579737 @default.
• W4312138110 hasAuthorship W4312138110A5083357248 @default.
• W4312138110 hasBestOaLocation W43121381101 @default.
• W4312138110 hasConcept C126322002 @default.
• W4312138110 hasConcept C177713679 @default.
• W4312138110 hasConcept C2777628635 @default.
• W4312138110 hasConcept C2778384902 @default.
• W4312138110 hasConcept C2908647359 @default.
• W4312138110 hasConcept C71924100 @default.
• W4312138110 hasConcept C86803240 @default.
• W4312138110 hasConcept C99454951 @default.
• W4312138110 hasConceptScore W4312138110C126322002 @default.
• W4312138110 hasConceptScore W4312138110C177713679 @default.
• W4312138110 hasConceptScore W4312138110C2777628635 @default.
• W4312138110 hasConceptScore W4312138110C2778384902 @default.
• W4312138110 hasConceptScore W4312138110C2908647359 @default.
• W4312138110 hasConceptScore W4312138110C71924100 @default.
• W4312138110 hasConceptScore W4312138110C86803240 @default.
• W4312138110 hasConceptScore W4312138110C99454951 @default.
• W4312138110 hasFunder F4320321102 @default.
• W4312138110 hasLocation W43121381101 @default.
• W4312138110 hasLocation W43121381102 @default.
• W4312138110 hasLocation W43121381103 @default.
• W4312138110 hasOpenAccess W4312138110 @default.
• W4312138110 hasPrimaryLocation W43121381101 @default.
• W4312138110 hasRelatedWork W1984304831 @default.
• W4312138110 hasRelatedWork W2015975988 @default.
• W4312138110 hasRelatedWork W2085452577 @default.
• W4312138110 hasRelatedWork W2141522520 @default.
• W4312138110 hasRelatedWork W2406430194 @default.
• W4312138110 hasRelatedWork W2994793273 @default.
• W4312138110 hasRelatedWork W2997146678 @default.
• W4312138110 hasRelatedWork W3025110062 @default.
• W4312138110 hasRelatedWork W4292539933 @default.
• W4312138110 hasRelatedWork W2377678510 @default.
• W4312138110 hasVolume "12" @default.
• W4312138110 isParatext "false" @default.
• W4312138110 isRetracted "false" @default.
• W4312138110 workType "article" @default.