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- W4312139545 abstract "<h3>Objectives</h3> Microbiome plays an important role in the development of different cancer types. Vaginal microbiome constitutes a new study field. We aim to examine the vaginal microbiome profile in patients with newly diagnosed epithelial ovarian cancer (EOC) compared to healthy women. <h3>Methods</h3> A prospective cohort study was conducted for evaluating the vaginal microbiome in patients with newly diagnosed EOC who are chemotherapy-naïve, compared to healthy controls. Samples were collected using a swab. DNA was extracted and amplified by PCR using universal primers of the prokaryotic 16S ribosomal RNA gene. Next-generation sequencing and taxonomical classification of bacterial species was performed. <h3>Results</h3> Vaginal swab samples were collected from 18 EOC patients, and 22 controls. Higher rates of menopausal status were demonstrated in cancer patient (77.8% to 41% P=0.041). The microbiome profile analysis revealed statistically significant differences between groups; Peptoniphilus coxii and Veillonella dispar/parvula were found to be more abundant in the cancer patients (p=0.034 and p=0.022, respectively). One bacterial family was also prominent- Lachnospiraceae (p=0.024). <h3>Conclusions</h3> In this innovative study, we demonstrated a significant difference in vaginal microbiome of ovarian cancer patients compared to healthy controls. Interestingly, these bacterial species that were prominent in ovarian cancer patients where previously linked to other malignancies such as lung and colon cancer. As described in previous studies, lactic acid producing bacteria were associated with a healthy microbiome. A possible mechanism that can be suggested here is lactic acid consumption by these bacteria. Expanding research in this field may lead to early diagnosis, disease prevention, and targeted therapy in patients with EOC." @default.
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- W4312139545 date "2022-12-01" @default.
- W4312139545 modified "2023-10-11" @default.
- W4312139545 title "EP223/#762 Distinct vaginal microbiome in newly diagnosed ovarian cancer patients" @default.
- W4312139545 doi "https://doi.org/10.1136/ijgc-2022-igcs.314" @default.
- W4312139545 hasPublicationYear "2022" @default.
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