Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312139622> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4312139622 abstract "<h3>Objectives</h3> The purpose of this study was to evaluate the impact of BRCA mutation status on survival among patients with epithelial ovarian, primary peritoneal or fallopian tube cancer (EOC) and brain metastasis (BM). <h3>Methods</h3> Single institution retrospective study of EOC patients who had access to germline and somatic genetic testing from 2017–2020. Genetic status, oncologic data and demographics were abstracted from medical records. Descriptive statistics were performed. <h3>Results</h3> From 2017–2020, 449 patients underwent germline genetic testing, and 308 patients underwent somatic testing. BM incidence was 2.04% (1/49) among germline BRCA (gBRCA) mutated cases, 14.58% (7/48) among somatic BRCA (sBRCA) mutated cases, and 3.41% (12/352) among patients without germline or somatic BRCA mutations (non-BRCA) (p=.001). Median time from initial diagnosis to diagnosis with BM was 38 months for gBRCA, 29 months for sBRCA, and 23 months for non-BRCA cases. Two cases were diagnosed with BM at initial diagnosis. Median time to death after BM diagnosis is not reached for gBRCA, 27 months for sBRCA, and 12.5 months for non-BRCA cases. There was no difference in the number of isolated BM between groups; systemic disease was present at the time of BM diagnosis for 16/20 (80%). <h3>Conclusions</h3> This is the first report describing outcomes of EOC with BM incorporating germline and somatic genetic data. BMs were most frequent in sBRCA patients. Survival after BM diagnosis was longest for the gBRCA, followed by sBRCA, and shortest for non-BRCA cases. The presence of BRCA mutations, germline or somatic, may represent a favorable prognostic factor if BM are diagnosed." @default.
- W4312139622 created "2023-01-04" @default.
- W4312139622 creator A5006618032 @default.
- W4312139622 creator A5010544827 @default.
- W4312139622 creator A5024416023 @default.
- W4312139622 creator A5050318574 @default.
- W4312139622 creator A5053103530 @default.
- W4312139622 creator A5056471101 @default.
- W4312139622 creator A5059150622 @default.
- W4312139622 date "2022-12-01" @default.
- W4312139622 modified "2023-09-26" @default.
- W4312139622 title "EP257/#1025 Does genetic status influence time to death after diagnosis with brain metastasis in ovarian cancer?" @default.
- W4312139622 doi "https://doi.org/10.1136/ijgc-2022-igcs.348" @default.
- W4312139622 hasPublicationYear "2022" @default.
- W4312139622 type Work @default.
- W4312139622 citedByCount "0" @default.
- W4312139622 crossrefType "proceedings-article" @default.
- W4312139622 hasAuthorship W4312139622A5006618032 @default.
- W4312139622 hasAuthorship W4312139622A5010544827 @default.
- W4312139622 hasAuthorship W4312139622A5024416023 @default.
- W4312139622 hasAuthorship W4312139622A5050318574 @default.
- W4312139622 hasAuthorship W4312139622A5053103530 @default.
- W4312139622 hasAuthorship W4312139622A5056471101 @default.
- W4312139622 hasAuthorship W4312139622A5059150622 @default.
- W4312139622 hasBestOaLocation W43121396221 @default.
- W4312139622 hasConcept C104317684 @default.
- W4312139622 hasConcept C109825262 @default.
- W4312139622 hasConcept C121608353 @default.
- W4312139622 hasConcept C126322002 @default.
- W4312139622 hasConcept C134305767 @default.
- W4312139622 hasConcept C13514818 @default.
- W4312139622 hasConcept C143998085 @default.
- W4312139622 hasConcept C2778164965 @default.
- W4312139622 hasConcept C2779013556 @default.
- W4312139622 hasConcept C2780427987 @default.
- W4312139622 hasConcept C2780673598 @default.
- W4312139622 hasConcept C501734568 @default.
- W4312139622 hasConcept C54355233 @default.
- W4312139622 hasConcept C71924100 @default.
- W4312139622 hasConcept C86803240 @default.
- W4312139622 hasConceptScore W4312139622C104317684 @default.
- W4312139622 hasConceptScore W4312139622C109825262 @default.
- W4312139622 hasConceptScore W4312139622C121608353 @default.
- W4312139622 hasConceptScore W4312139622C126322002 @default.
- W4312139622 hasConceptScore W4312139622C134305767 @default.
- W4312139622 hasConceptScore W4312139622C13514818 @default.
- W4312139622 hasConceptScore W4312139622C143998085 @default.
- W4312139622 hasConceptScore W4312139622C2778164965 @default.
- W4312139622 hasConceptScore W4312139622C2779013556 @default.
- W4312139622 hasConceptScore W4312139622C2780427987 @default.
- W4312139622 hasConceptScore W4312139622C2780673598 @default.
- W4312139622 hasConceptScore W4312139622C501734568 @default.
- W4312139622 hasConceptScore W4312139622C54355233 @default.
- W4312139622 hasConceptScore W4312139622C71924100 @default.
- W4312139622 hasConceptScore W4312139622C86803240 @default.
- W4312139622 hasLocation W43121396221 @default.
- W4312139622 hasOpenAccess W4312139622 @default.
- W4312139622 hasPrimaryLocation W43121396221 @default.
- W4312139622 hasRelatedWork W2159462692 @default.
- W4312139622 hasRelatedWork W2231755720 @default.
- W4312139622 hasRelatedWork W2396892895 @default.
- W4312139622 hasRelatedWork W2551427875 @default.
- W4312139622 hasRelatedWork W2589697688 @default.
- W4312139622 hasRelatedWork W2954059625 @default.
- W4312139622 hasRelatedWork W2955322959 @default.
- W4312139622 hasRelatedWork W3096738405 @default.
- W4312139622 hasRelatedWork W4200154777 @default.
- W4312139622 hasRelatedWork W4237694891 @default.
- W4312139622 isParatext "false" @default.
- W4312139622 isRetracted "false" @default.
- W4312139622 workType "article" @default.