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- W4312139713 abstract "<h3>Objectives</h3> Carcinosarcoma is a high-grade endometrial carcinoma (EC) that consists of a carcinomatous component juxtaposed with a malignant metaplastic stromal component. Our aim was to assess the molecular subtype(s) of carcinosarcomas in a population-based cohort. <h3>Methods</h3> We assessed IHC and NGS data on all cases diagnosed as carcinosarcoma and undertook expert pathology review. <h3>Results</h3> Of 1221 ECs identified across 29 centers, 41 carcinosarcomas were diagnosed. 37 (91.2%) were p53abn, 2 (4.9%) were NSMP and 1 each (2.4%) were POLEmut and MMRd, respectively. All cases were reviewed by 2 expert pathologists blinded to molecular data. In 22 cases (53.7%) histology was confirmed as carcinosarcoma on review and all of these were p53abn. Of the remaining 19 cases where diagnosis of carcinosarcoma was not verified, 3 showed an undifferentiated or dedifferentiated morphology, 6 showed corded and hyalinized (CHEC) features, 3 showed prominent reactive spindle cell stroma, and 1 showed features of adenosarcoma. For the remaining 6 cases, the submitted representative slide available for review 5 cases and 1 case had only the epithelial and sarcomatous component, respectively. Of the non-p53abn tumors, on review all had only epithelial component, one NSMP tumors was CHEC pattern endometrioid EC (EEC), MMRd tumor was a grade 1 EEC and the POLEmut tumor was grade 3 EEC with spindle cell growth. <h3>Conclusions</h3> In this series, all pathology confirmed endometrial carcinosarcomas were p53abn; the finding of any other molecular subtype warrants pathology review. Endometrioid carcinoma with corded and hyalinized growth pattern, de-differentiated/undifferentiated carcinoma and sarcomatous overgrowth of adenosarcoma can all mimic carcinosarcoma." @default.
- W4312139713 created "2023-01-04" @default.
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- W4312139713 date "2022-12-01" @default.
- W4312139713 modified "2023-09-26" @default.
- W4312139713 title "EP114/#506 Molecular classification of endometrial carcinosarcoma shows uniformly P53ABN subtype and provide opportunities for diagnostic improvement" @default.
- W4312139713 doi "https://doi.org/10.1136/ijgc-2022-igcs.205" @default.
- W4312139713 hasPublicationYear "2022" @default.
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