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- W4312139720 abstract "<h3>Objectives</h3> The E2A and inhibitor of DNA binding (ID) proteins are transcription factors involved in cell cycle regulation and cellular differentiation. Imbalance of ID/E2A activity is associated with oncogenesis in various tumors, but their expression patterns and prognostic values are still unknown. We evaluated ID and E2A expression in ovarian cancer cells and assessed the possibility of reprogramming ovarian cellular homeostasis by restoring the ID/E2A axis. <h3>Methods</h3> We analyzed copy number alterations, mutations, methylations, and mRNA expressions of ID 1 – 4 and E2A using The Cancer Genome Atlas data of 570 ovarian serous cystadenocarcinoma patients. We also determined the effect of E2A induction on ovarian cancer cell growth in vitro and in vivo using SKOV-3/Luc cells transduced with tamoxifen-inducible E47, a splice variant of E2A. <h3>Results</h3> Incidentally, 97.2% cases exhibited gain of ID 1 – 4 or loss of E2A. Predominantly, ID 1 – 4 were hypomethylated, while E2A was hypermethylated. Immunohistochemical analysis revealed that ID-3 and ID-4 expressions were high while E2A expression was low in cancerous ovarian tissues. Correlation analysis of ID and E2A levels with survival outcomes of ovarian cancer patients indicated that patients with high ID-3 levels had poor overall survival. Interestingly, E47 induced SKOV-3 cell death in vitro and inhibited tumor growth in SKOV-3 implanted mice. <h3>Conclusions</h3> Therefore, restoring ID/E2A balance is a promising approach for treating ovarian cancer." @default.
- W4312139720 created "2023-01-04" @default.
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- W4312139720 date "2022-12-01" @default.
- W4312139720 modified "2023-09-26" @default.
- W4312139720 title "EP254/#715 Expression profiles of id and E2A in ovarian cancer and sup-pression of ovarian cancer by the E2A isoform E47" @default.
- W4312139720 doi "https://doi.org/10.1136/ijgc-2022-igcs.345" @default.
- W4312139720 hasPublicationYear "2022" @default.
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