FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312140764> ?p ?o ?g. }

• W4312140764 endingPage "137633" @default.
• W4312140764 startingPage "137633" @default.
• W4312140764 abstract "Humans are ubiquitously exposed to endocrine disrupting chemicals (EDCs), substances that interfere with endogenous hormonal signaling. Exposure during early development is of particular concern due to the programming role of hormones during this period. A previous epidemiological study has shown association between prenatal co-exposure to 8 EDCs (Mixture N1) and language delay in children, suggesting an effect of this mixture on neurodevelopment. Furthermore, in utero exposure to Mixture N1 altered gene expression and behavior in adult mice. In this study, we investigated whether epigenetic mechanisms could underlie the long term effects of Mixture N1 on gene expression and behavior. To this end, we analyzed DNA methylation at regulatory regions of genes whose expression was affected by Mixture N1 in the hippocampus of in utero exposed mice using bisulfite-pyrosequencing. We show that Mixture N1 decreases DNA methylation in males at three genes that are part of the hypothalamus-pituitary-adrenal (HPA) axis: Nr3c1, Nr3c2, and Crhr1, coding for the glucocorticoid receptor, the mineralocorticoid receptor, and the corticotropin releasing hormone receptor 1, respectively. Furthermore, we show that the decrease in Nr3c1 methylation correlates with increased gene expression, and that Nr3c1, Nr3c2, and Crhr1 methylation correlates with hyperactivity and reduction in social behavior. These findings indicate that an EDC mixture corresponding to a human exposure scenario induces epigenetic changes, and thus programming effects, on the HPA axis that are reflected in the behavioral phenotypes of the adult male offspring." @default.
• W4312140764 created "2023-01-04" @default.
• W4312140764 creator A5000221775 @default.
• W4312140764 creator A5023877434 @default.
• W4312140764 creator A5025497774 @default.
• W4312140764 creator A5031165242 @default.
• W4312140764 creator A5035033741 @default.
• W4312140764 creator A5061794956 @default.
• W4312140764 creator A5071015677 @default.
• W4312140764 creator A5072182289 @default.
• W4312140764 creator A5084551780 @default.
• W4312140764 creator A5085681018 @default.
• W4312140764 date "2023-02-01" @default.
• W4312140764 modified "2023-10-07" @default.
• W4312140764 title "A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice" @default.
• W4312140764 cites W1572525448 @default.
• W4312140764 cites W1588280270 @default.
• W4312140764 cites W1778662842 @default.
• W4312140764 cites W1968179768 @default.
• W4312140764 cites W1970582968 @default.
• W4312140764 cites W1982232439 @default.
• W4312140764 cites W1984573399 @default.
• W4312140764 cites W1986576876 @default.
• W4312140764 cites W1987557775 @default.
• W4312140764 cites W1994689667 @default.
• W4312140764 cites W2014980780 @default.
• W4312140764 cites W2037269393 @default.
• W4312140764 cites W2044819518 @default.
• W4312140764 cites W2048637593 @default.
• W4312140764 cites W2063864578 @default.
• W4312140764 cites W2063946921 @default.
• W4312140764 cites W2073278098 @default.
• W4312140764 cites W2079889983 @default.
• W4312140764 cites W2086608423 @default.
• W4312140764 cites W2101160904 @default.
• W4312140764 cites W2106976893 @default.
• W4312140764 cites W2120546159 @default.
• W4312140764 cites W2124209493 @default.
• W4312140764 cites W2146416965 @default.
• W4312140764 cites W2148337554 @default.
• W4312140764 cites W2148619299 @default.
• W4312140764 cites W2148722053 @default.
• W4312140764 cites W2149578387 @default.
• W4312140764 cites W2155826941 @default.
• W4312140764 cites W2159544425 @default.
• W4312140764 cites W2165451199 @default.
• W4312140764 cites W2298392052 @default.
• W4312140764 cites W2328390917 @default.
• W4312140764 cites W2412578066 @default.
• W4312140764 cites W2564731929 @default.
• W4312140764 cites W2567689948 @default.
• W4312140764 cites W2599553288 @default.
• W4312140764 cites W2604506224 @default.
• W4312140764 cites W2616178001 @default.
• W4312140764 cites W2634335102 @default.
• W4312140764 cites W2736349296 @default.
• W4312140764 cites W2789662155 @default.
• W4312140764 cites W2793857564 @default.
• W4312140764 cites W2806052858 @default.
• W4312140764 cites W2810143528 @default.
• W4312140764 cites W2883852411 @default.
• W4312140764 cites W2884189203 @default.
• W4312140764 cites W2891507167 @default.
• W4312140764 cites W2967422213 @default.
• W4312140764 cites W2982015589 @default.
• W4312140764 cites W2985699996 @default.
• W4312140764 cites W2992064964 @default.
• W4312140764 cites W3005983687 @default.
• W4312140764 cites W3023341510 @default.
• W4312140764 cites W3033666138 @default.
• W4312140764 cites W3044669430 @default.
• W4312140764 cites W3106602329 @default.
• W4312140764 cites W3123154668 @default.
• W4312140764 cites W3157923161 @default.
• W4312140764 cites W3163217353 @default.
• W4312140764 cites W3165866464 @default.
• W4312140764 cites W3194868743 @default.
• W4312140764 cites W3197592599 @default.
• W4312140764 cites W4280581047 @default.
• W4312140764 doi "https://doi.org/10.1016/j.chemosphere.2022.137633" @default.
• W4312140764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36565761" @default.
• W4312140764 hasPublicationYear "2023" @default.
• W4312140764 type Work @default.
• W4312140764 citedByCount "0" @default.
• W4312140764 crossrefType "journal-article" @default.
• W4312140764 hasAuthorship W4312140764A5000221775 @default.
• W4312140764 hasAuthorship W4312140764A5023877434 @default.
• W4312140764 hasAuthorship W4312140764A5025497774 @default.
• W4312140764 hasAuthorship W4312140764A5031165242 @default.
• W4312140764 hasAuthorship W4312140764A5035033741 @default.
• W4312140764 hasAuthorship W4312140764A5061794956 @default.
• W4312140764 hasAuthorship W4312140764A5071015677 @default.
• W4312140764 hasAuthorship W4312140764A5072182289 @default.
• W4312140764 hasAuthorship W4312140764A5084551780 @default.
• W4312140764 hasAuthorship W4312140764A5085681018 @default.
• W4312140764 hasBestOaLocation W43121407641 @default.
• W4312140764 hasConcept C104317684 @default.
• W4312140764 hasConcept C112672928 @default.

• next