Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312140930> ?p ?o ?g. }
- W4312140930 abstract "Plasma lipid transport and metabolism are essential to ensure correct cellular function throughout the body. Dynamically regulated in time and space, the well-characterized mechanisms underpinning plasma lipid transport and metabolism offers an enticing, but as yet underexplored, rationale to design synthetic lipid nanoparticles with inherent cell/tissue selectivity. Herein, a systemically administered liposome formulation, composed of just two lipids, that is capable of hijacking a triglyceride lipase-mediated lipid transport pathway resulting in liposome recognition and uptake within specific endothelial cell subsets is described. In the absence of targeting ligands, liposome-lipase interactions are mediated by a unique, phase-separated (parachute) liposome morphology. Within the embryonic zebrafish, selective liposome accumulation is observed at the developing blood-brain barrier. In mice, extensive liposome accumulation within the liver and spleen - which is reduced, but not eliminated, following small molecule lipase inhibition - supports a role for endothelial lipase but highlights these liposomes are also subject to significant off-target by reticuloendothelial system organs. Overall, these compositionally simplistic liposomes offer new insights into the discovery and design of lipid-based nanoparticles that can exploit endogenous lipid transport and metabolism pathways to achieve cell selective targeting in vivo." @default.
- W4312140930 created "2023-01-04" @default.
- W4312140930 creator A5007359710 @default.
- W4312140930 creator A5012597588 @default.
- W4312140930 creator A5015141197 @default.
- W4312140930 creator A5025617905 @default.
- W4312140930 creator A5026487296 @default.
- W4312140930 creator A5034843111 @default.
- W4312140930 creator A5034886170 @default.
- W4312140930 creator A5039085181 @default.
- W4312140930 creator A5062821752 @default.
- W4312140930 creator A5082191409 @default.
- W4312140930 creator A5082199111 @default.
- W4312140930 date "2023-01-19" @default.
- W4312140930 modified "2023-09-26" @default.
- W4312140930 title "Phase‐Separated Liposomes Hijack Endogenous Lipoprotein Transport and Metabolism Pathways to Target Subsets of Endothelial Cells In Vivo" @default.
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