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• W4312141979 abstract "Proton pump inhibitors (PPIs) have several limitations to their efficacy including insufficient acid suppression, slow onset of action, and variable efficacy among patients due to CYP2C19 metabolism. Potassium-competitive acid blockers inhibit H+-K+-ATPase in a reversible and K+-competitive manner, are novel acid suppressive drugs with rapid onset of action, meal independence, and prolonged control of intragastric acidity compared to PPIs. Potassium-competitive acid blockers exhibited non-inferior therapeutic efficacies on reflux esophagitis, gastric ulcers, and Helicobacter pylori eradication. The review is focused on the unmet needs across the acid-related diseases and recent updates on clinical studies using vonoprazan and tegoprazan." @default.
• W4312141979 created "2023-01-04" @default.
• W4312141979 creator A5030459098 @default.
• W4312141979 date "2022-12-25" @default.
• W4312141979 modified "2023-10-18" @default.
• W4312141979 title "Treatment of Acid-related Diseases Using Potassium-competitive Acid Blockers" @default.
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• W4312141979 doi "https://doi.org/10.4166/kjg.2022.143" @default.
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