Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312156105> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4312156105 abstract "Milvexian (BMS-986177/JNJ-70033093) is a potent, oral small molecule that inhibits the active form of factor XI with high affinity and selectivity. This study assessed the single-dose pharmacokinetic and pharmacodynamic properties of milvexian co-administered with rifampin, an organic anion transport protein (OATP) inhibitor and potent cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp) inducer. In this open-label, nonrandomized, single-sequence study, healthy participants (N = 16) received single doses of milvexian on Day 1 (100 mg), milvexian and rifampin (600 mg) on Day 4, rifampin on Days 5-11, milvexian and rifampin on Day 12, and rifampin on Days 13-14. Pharmacokinetic data were summarized using descriptive statistics. Administration of milvexian, alone or in combination with rifampin, was generally safe and well tolerated. Single-dose co-administration of rifampin and milvexian demonstrated no meaningful changes in milvexian exposure versus milvexian alone (Cmax, 110%; AUC[0-T], 102%; AUC[INF], 101%). After multiple doses of rifampin and milvexian, peak and total milvexian exposure substantially decreased versus milvexian alone (Cmax, 22%; AUC[0-T], 15%; AUC[INF], 15%). Results were consistent with preclinical data, indicating that milvexian is a substrate for CYP3A4/5 and P-gp but not OATP. The implications of these results on the need for dose adjustment of milvexian will be further elucidated following the completion of phase 2 and 3 trials.Trial registration The study was registered with ClinicalTrials.gov (NCT02959060; submitted 7/11/2016, first posted 8/11/2016)." @default.
- W4312156105 created "2023-01-04" @default.
- W4312156105 creator A5003969862 @default.
- W4312156105 creator A5017541508 @default.
- W4312156105 creator A5026463840 @default.
- W4312156105 creator A5032142814 @default.
- W4312156105 creator A5038984243 @default.
- W4312156105 creator A5067059128 @default.
- W4312156105 creator A5077743426 @default.
- W4312156105 creator A5086797931 @default.
- W4312156105 creator A5088474365 @default.
- W4312156105 date "2022-12-23" @default.
- W4312156105 modified "2023-09-25" @default.
- W4312156105 title "Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor" @default.
- W4312156105 cites W1979338133 @default.
- W4312156105 cites W1981300426 @default.
- W4312156105 cites W1984409558 @default.
- W4312156105 cites W2016493538 @default.
- W4312156105 cites W2022545732 @default.
- W4312156105 cites W2044906812 @default.
- W4312156105 cites W2051375078 @default.
- W4312156105 cites W2079416873 @default.
- W4312156105 cites W2105634155 @default.
- W4312156105 cites W2140848039 @default.
- W4312156105 cites W2338854794 @default.
- W4312156105 cites W2350361926 @default.
- W4312156105 cites W3005539395 @default.
- W4312156105 cites W3197364065 @default.
- W4312156105 cites W3201159048 @default.
- W4312156105 cites W4220841041 @default.
- W4312156105 doi "https://doi.org/10.1038/s41598-022-25936-2" @default.
- W4312156105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36564395" @default.
- W4312156105 hasPublicationYear "2022" @default.
- W4312156105 type Work @default.
- W4312156105 citedByCount "3" @default.
- W4312156105 countsByYear W43121561052023 @default.
- W4312156105 crossrefType "journal-article" @default.
- W4312156105 hasAuthorship W4312156105A5003969862 @default.
- W4312156105 hasAuthorship W4312156105A5017541508 @default.
- W4312156105 hasAuthorship W4312156105A5026463840 @default.
- W4312156105 hasAuthorship W4312156105A5032142814 @default.
- W4312156105 hasAuthorship W4312156105A5038984243 @default.
- W4312156105 hasAuthorship W4312156105A5067059128 @default.
- W4312156105 hasAuthorship W4312156105A5077743426 @default.
- W4312156105 hasAuthorship W4312156105A5086797931 @default.
- W4312156105 hasAuthorship W4312156105A5088474365 @default.
- W4312156105 hasBestOaLocation W43121561051 @default.
- W4312156105 hasConcept C104317684 @default.
- W4312156105 hasConcept C109650736 @default.
- W4312156105 hasConcept C111113717 @default.
- W4312156105 hasConcept C112705442 @default.
- W4312156105 hasConcept C11824378 @default.
- W4312156105 hasConcept C126322002 @default.
- W4312156105 hasConcept C149011108 @default.
- W4312156105 hasConcept C185592680 @default.
- W4312156105 hasConcept C22979827 @default.
- W4312156105 hasConcept C2776678969 @default.
- W4312156105 hasConcept C2777056448 @default.
- W4312156105 hasConcept C526171541 @default.
- W4312156105 hasConcept C55493867 @default.
- W4312156105 hasConcept C62231903 @default.
- W4312156105 hasConcept C71924100 @default.
- W4312156105 hasConcept C98274493 @default.
- W4312156105 hasConceptScore W4312156105C104317684 @default.
- W4312156105 hasConceptScore W4312156105C109650736 @default.
- W4312156105 hasConceptScore W4312156105C111113717 @default.
- W4312156105 hasConceptScore W4312156105C112705442 @default.
- W4312156105 hasConceptScore W4312156105C11824378 @default.
- W4312156105 hasConceptScore W4312156105C126322002 @default.
- W4312156105 hasConceptScore W4312156105C149011108 @default.
- W4312156105 hasConceptScore W4312156105C185592680 @default.
- W4312156105 hasConceptScore W4312156105C22979827 @default.
- W4312156105 hasConceptScore W4312156105C2776678969 @default.
- W4312156105 hasConceptScore W4312156105C2777056448 @default.
- W4312156105 hasConceptScore W4312156105C526171541 @default.
- W4312156105 hasConceptScore W4312156105C55493867 @default.
- W4312156105 hasConceptScore W4312156105C62231903 @default.
- W4312156105 hasConceptScore W4312156105C71924100 @default.
- W4312156105 hasConceptScore W4312156105C98274493 @default.
- W4312156105 hasIssue "1" @default.
- W4312156105 hasLocation W43121561051 @default.
- W4312156105 hasLocation W43121561052 @default.
- W4312156105 hasLocation W43121561053 @default.
- W4312156105 hasLocation W43121561054 @default.
- W4312156105 hasOpenAccess W4312156105 @default.
- W4312156105 hasPrimaryLocation W43121561051 @default.
- W4312156105 hasRelatedWork W1544870047 @default.
- W4312156105 hasRelatedWork W1556453740 @default.
- W4312156105 hasRelatedWork W1566015146 @default.
- W4312156105 hasRelatedWork W1928886399 @default.
- W4312156105 hasRelatedWork W2021250530 @default.
- W4312156105 hasRelatedWork W2132019166 @default.
- W4312156105 hasRelatedWork W2766550598 @default.
- W4312156105 hasRelatedWork W2889287604 @default.
- W4312156105 hasRelatedWork W3158244131 @default.
- W4312156105 hasRelatedWork W4225384168 @default.
- W4312156105 hasVolume "12" @default.
- W4312156105 isParatext "false" @default.
- W4312156105 isRetracted "false" @default.
- W4312156105 workType "article" @default.