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- W4312156693 abstract "Modifications to the enzymatic glycosylation of vancomycin and its residue 4 thioamide analogue are detailed that significantly reduce the enzyme loading and amount of glycosyl donor needed for each glycosylation reaction, provide a streamlined synthesis and replacement for the synthetic UDP-vancosamine glycosyl donor to improve both access and storage stability, and permit a single-pot, two-step conversion of the aglycons to the fully glycosylated synthetic glycopeptides now conducted at higher concentrations. The improvements are exemplified with the two-step, one-pot glycosylation of [Ψ[C(=S)NH]Tpg4]vancomycin aglycon (92%) conducted on a 400 mg scale (2 mg–1 g scales) and vancomycin aglycon itself (5 mg scale, 84%)." @default.
- W4312156693 created "2023-01-04" @default.
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- W4312156693 date "2023-01-01" @default.
- W4312156693 modified "2023-10-01" @default.
- W4312156693 title "Improved preparative enzymatic glycosylation of vancomycin aglycon and analogues" @default.
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- W4312156693 doi "https://doi.org/10.1016/j.tet.2022.133211" @default.
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