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- W4312173618 abstract "Lung cancer (LC) is one of the most incident malignancies and a leading cause of cancer mortality worldwide. Common tumorigenic drivers of LC mainly include genetic alterations of EGFR, ALK, KRAS, BRAF, ROS1, and MET. Small inhibitory molecules and antibodies selectively targeting these alterations or/and their downstream signaling pathways have been approved for treatment of LC. Unfortunately, following initial positive responses to these targeted therapies, a large number of patients show dismal prognosis due to the occurrence of resistance mechanisms, such as novel mutations of these genes and activation of alternative signaling pathways. Over the past decade, it has become clear that there is no possible cure for LC unless potent antitumor immune responses are induced by therapeutic intervention. Immunogenic cell death (ICD) is a newly emerged concept, a form of regulated cell death that is sufficient to activate adaptive immune responses against tumor cells. It transforms dying cancer cells into a therapeutic vaccine and stimulates long-lasting protective antitumor immunity. In this review, we discuss the key targetable genetic aberrations and the underlying mechanism of ICD in LC. Various agents inducing ICD are summarized and the possibility of harnessing ICD in LC immunotherapy is further explored." @default.
- W4312173618 created "2023-01-04" @default.
- W4312173618 creator A5009490989 @default.
- W4312173618 creator A5034762999 @default.
- W4312173618 creator A5039545694 @default.
- W4312173618 creator A5066655076 @default.
- W4312173618 creator A5073568638 @default.
- W4312173618 creator A5081534428 @default.
- W4312173618 date "2022-12-23" @default.
- W4312173618 modified "2023-10-02" @default.
- W4312173618 title "From targeted therapy to a novel way: Immunogenic cell death in lung cancer" @default.
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