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- W4312180643 abstract "Abstract Environmental effects on gene expression and offspring development can be mediated by epigenetic modifications. It is well established that maternal diet influences DNA methylation patterns and phenotypes in the offspring; however, the epigenetic effects of paternal diet on developing offspring warrants further investigation. Here, we examined how a prepubertal methionine-enriched paternal diet affected sperm DNA methylation and its subsequent effects on embryo gene expression. Three treatment and three control rams were bred to seven ewes, and blastocysts were flushed for RNA extraction. Semen was collected from all rams and submitted for reduced representation bisulfite sequencing analysis. In total, 166 differentially methylated cytosines were identified in the sperm from treatment versus control rams. Nine genes were found to be differentially expressed in embryos produced from treatment versus control rams, and seven differentially methylated cytosines in the sperm were found to be highly correlated with gene expression in the embryos. Our results demonstrate that sperm methylation differences induced by diet may influence fetal programming." @default.
- W4312180643 created "2023-01-04" @default.
- W4312180643 creator A5009389514 @default.
- W4312180643 creator A5011991140 @default.
- W4312180643 creator A5053294157 @default.
- W4312180643 creator A5070241693 @default.
- W4312180643 date "2022-12-23" @default.
- W4312180643 modified "2023-09-30" @default.
- W4312180643 title "Effects of paternal methionine supplementation on sperm DNA methylation and embryo transcriptome in sheep" @default.
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- W4312180643 doi "https://doi.org/10.1093/eep/dvac029" @default.
- W4312180643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36727109" @default.
- W4312180643 hasPublicationYear "2022" @default.
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