FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312186502> ?p ?o ?g. }

• W4312186502 abstract "Neonatal porcine islet-like cell clusters (NPICCs) are a promising source for islet cell transplantation. Excellent islet quality is important to achieve a cure for type 1 diabetes. We investigated formation of cell clusters from dispersed NPICCs on microwell cell culture plates, evaluated the composition of re-aggregated porcine islets (REPIs) and compared in vivo function by transplantation into diabetic NOD‐SCID IL2rγ −/− (NSG) mice with native NPICCs. Dissociation of NPICCs into single cells and re-aggregation resulted in the formation of uniform REPI clusters. A higher prevalence of normoglycemia was observed in diabetic NSG mice after transplantation with a limited number ( n = 1500) of REPIs (85.7%) versus NPICCs ( n = 1500) (33.3%) ( p &lt; 0.05). Transplanted REPIs and NPICCs displayed a similar architecture of endocrine and endothelial cells. Intraperitoneal glucose tolerance tests revealed an improved beta cell function after transplantation of 1500 REPIs (AUC glucose 0–120 min 6260 ± 305.3) as compared to transplantation of 3000 native NPICCs (AUC glucose 0–120 min 8073 ± 536.2) ( p &lt; 0.01). Re-aggregation of single cells from dissociated NPICCs generates cell clusters with excellent functionality and improved in vivo function as compared to native NPICCs." @default.
• W4312186502 created "2023-01-04" @default.
• W4312186502 creator A5009401408 @default.
• W4312186502 creator A5016243172 @default.
• W4312186502 creator A5018887530 @default.
• W4312186502 creator A5024398800 @default.
• W4312186502 creator A5025136768 @default.
• W4312186502 creator A5028342444 @default.
• W4312186502 creator A5035903269 @default.
• W4312186502 creator A5045590930 @default.
• W4312186502 creator A5047469315 @default.
• W4312186502 creator A5086201984 @default.
• W4312186502 date "2022-12-22" @default.
• W4312186502 modified "2023-10-18" @default.
• W4312186502 title "Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves In Vitro Function and Transplantation Outcome" @default.
• W4312186502 cites W1579420638 @default.
• W4312186502 cites W1614547515 @default.
• W4312186502 cites W1925269365 @default.
• W4312186502 cites W1985726058 @default.
• W4312186502 cites W2004126648 @default.
• W4312186502 cites W2004820178 @default.
• W4312186502 cites W2036996065 @default.
• W4312186502 cites W2037046149 @default.
• W4312186502 cites W2046436291 @default.
• W4312186502 cites W2056138898 @default.
• W4312186502 cites W2074332806 @default.
• W4312186502 cites W2078657091 @default.
• W4312186502 cites W2103330398 @default.
• W4312186502 cites W2160639244 @default.
• W4312186502 cites W2165262973 @default.
• W4312186502 cites W2165817281 @default.
• W4312186502 cites W2462848664 @default.
• W4312186502 cites W2623144772 @default.
• W4312186502 cites W2740963940 @default.
• W4312186502 cites W2747754797 @default.
• W4312186502 cites W2791423015 @default.
• W4312186502 cites W2810239357 @default.
• W4312186502 cites W2953479887 @default.
• W4312186502 cites W3047556281 @default.
• W4312186502 cites W3080116599 @default.
• W4312186502 cites W3107315729 @default.
• W4312186502 cites W4200512514 @default.
• W4312186502 cites W4220673480 @default.
• W4312186502 doi "https://doi.org/10.3389/ti.2022.10697" @default.
• W4312186502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685665" @default.
• W4312186502 hasPublicationYear "2022" @default.
• W4312186502 type Work @default.
• W4312186502 citedByCount "1" @default.
• W4312186502 countsByYear W43121865022023 @default.
• W4312186502 crossrefType "journal-article" @default.
• W4312186502 hasAuthorship W4312186502A5009401408 @default.
• W4312186502 hasAuthorship W4312186502A5016243172 @default.
• W4312186502 hasAuthorship W4312186502A5018887530 @default.
• W4312186502 hasAuthorship W4312186502A5024398800 @default.
• W4312186502 hasAuthorship W4312186502A5025136768 @default.
• W4312186502 hasAuthorship W4312186502A5028342444 @default.
• W4312186502 hasAuthorship W4312186502A5035903269 @default.
• W4312186502 hasAuthorship W4312186502A5045590930 @default.
• W4312186502 hasAuthorship W4312186502A5047469315 @default.
• W4312186502 hasAuthorship W4312186502A5086201984 @default.
• W4312186502 hasBestOaLocation W43121865021 @default.
• W4312186502 hasConcept C126322002 @default.
• W4312186502 hasConcept C134018914 @default.
• W4312186502 hasConcept C1491633281 @default.
• W4312186502 hasConcept C150903083 @default.
• W4312186502 hasConcept C165220095 @default.
• W4312186502 hasConcept C16685009 @default.
• W4312186502 hasConcept C202751555 @default.
• W4312186502 hasConcept C203014093 @default.
• W4312186502 hasConcept C207001950 @default.
• W4312186502 hasConcept C2778013207 @default.
• W4312186502 hasConcept C2781232474 @default.
• W4312186502 hasConcept C2911091166 @default.
• W4312186502 hasConcept C55493867 @default.
• W4312186502 hasConcept C555293320 @default.
• W4312186502 hasConcept C55851684 @default.
• W4312186502 hasConcept C71924100 @default.
• W4312186502 hasConcept C86803240 @default.
• W4312186502 hasConceptScore W4312186502C126322002 @default.
• W4312186502 hasConceptScore W4312186502C134018914 @default.
• W4312186502 hasConceptScore W4312186502C1491633281 @default.
• W4312186502 hasConceptScore W4312186502C150903083 @default.
• W4312186502 hasConceptScore W4312186502C165220095 @default.
• W4312186502 hasConceptScore W4312186502C16685009 @default.
• W4312186502 hasConceptScore W4312186502C202751555 @default.
• W4312186502 hasConceptScore W4312186502C203014093 @default.
• W4312186502 hasConceptScore W4312186502C207001950 @default.
• W4312186502 hasConceptScore W4312186502C2778013207 @default.
• W4312186502 hasConceptScore W4312186502C2781232474 @default.
• W4312186502 hasConceptScore W4312186502C2911091166 @default.
• W4312186502 hasConceptScore W4312186502C55493867 @default.
• W4312186502 hasConceptScore W4312186502C555293320 @default.
• W4312186502 hasConceptScore W4312186502C55851684 @default.
• W4312186502 hasConceptScore W4312186502C71924100 @default.
• W4312186502 hasConceptScore W4312186502C86803240 @default.
• W4312186502 hasFunder F4320320879 @default.
• W4312186502 hasFunder F4320332999 @default.
• W4312186502 hasLocation W43121865021 @default.
• W4312186502 hasLocation W43121865022 @default.
• W4312186502 hasLocation W43121865023 @default.

• next