FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312188802> ?p ?o ?g. }

• W4312188802 endingPage "1788" @default.
• W4312188802 startingPage "1779" @default.
• W4312188802 abstract "Abstract: Heterocycles having nitrogen and sulphur atoms attract chief attention due to their importance in diverse fields, especially in medicinal chemistry and pharmaceutical industry. Among those, 2-aminothiazole, one of the most flexible and pervasive heterocyclic scaffolds found in many natural and synthetic products, exhibits a wide variety of biological activities. A one-pot method for the synthesis of 2-aminothiazoles through Cu(II)-iodine-catalyzed Hantzsch condensation has been achieved for the first time. This novel green methodology facilitates the formation of a broad range of 2-aminothiazole derivatives utilizing catalytic quantities of Cu(II) salts and iodine, incorporating various methyl aryl ketones and thiourea as substrates. This novel strategy involves a Hantzsch-type condensation between thiourea and in situ generated α-iodoketones, formed from the reaction of methyl aryl ketones and iodine. The present protocol reveals PEG-400 as the best solvent, which furnishes moderate to good yields of the desired 2-aminothiazole derivatives. The addition of a catalytic quantity of copper acetate ensures the continuous availability of iodine for several catalytic cycles, as copper(II) allows the oxidation of iodide to iodine. The feasibility of this novel route is studied with electron-withdrawing, electron-donating, and halo-substituted derivatives of methyl aryl ketones with thiourea to confirm the functional group compatibility of the reaction. Moreover, this efficient strategy evades the direct use of noxious and lachrymatory α–halocarbonyls as reaction substrates and strong oxidants. Using a catalytic quantity of iodine in the reaction makes the separation of the desired products much easier by reducing the amount of unwanted side-products than utilizing a stoichiometric amount of iodine." @default.
• W4312188802 created "2023-01-04" @default.
• W4312188802 creator A5007240747 @default.
• W4312188802 creator A5076376734 @default.
• W4312188802 creator A5085131425 @default.
• W4312188802 date "2023-10-01" @default.
• W4312188802 modified "2023-10-11" @default.
• W4312188802 title "A Novel Cu(II)-Iodine Catalyzed Hantzsch Type Synthesis of 2-Aminothiazole Derivatives" @default.
• W4312188802 cites W161134873 @default.
• W4312188802 cites W1965504785 @default.
• W4312188802 cites W1970957276 @default.
• W4312188802 cites W1983970436 @default.
• W4312188802 cites W1985316308 @default.
• W4312188802 cites W1994977169 @default.
• W4312188802 cites W1997537913 @default.
• W4312188802 cites W2002733668 @default.
• W4312188802 cites W2073639158 @default.
• W4312188802 cites W2081711461 @default.
• W4312188802 cites W2095435139 @default.
• W4312188802 cites W2099936981 @default.
• W4312188802 cites W2107735600 @default.
• W4312188802 cites W2129284802 @default.
• W4312188802 cites W2136322711 @default.
• W4312188802 cites W2145640129 @default.
• W4312188802 cites W2147011116 @default.
• W4312188802 cites W2213059463 @default.
• W4312188802 cites W2238971919 @default.
• W4312188802 cites W2328500531 @default.
• W4312188802 cites W2329699586 @default.
• W4312188802 cites W2331484215 @default.
• W4312188802 cites W2511575431 @default.
• W4312188802 cites W2766251828 @default.
• W4312188802 cites W2767508186 @default.
• W4312188802 cites W2783272569 @default.
• W4312188802 cites W2802932796 @default.
• W4312188802 cites W2915183346 @default.
• W4312188802 cites W2949066893 @default.
• W4312188802 cites W2949145034 @default.
• W4312188802 cites W2950465916 @default.
• W4312188802 cites W2969994809 @default.
• W4312188802 cites W3014006505 @default.
• W4312188802 cites W3091304419 @default.
• W4312188802 cites W3092441512 @default.
• W4312188802 cites W3139396594 @default.
• W4312188802 cites W3147101878 @default.
• W4312188802 cites W3177886766 @default.
• W4312188802 doi "https://doi.org/10.2174/1385272827666221221103955" @default.
• W4312188802 hasPublicationYear "2023" @default.
• W4312188802 type Work @default.
• W4312188802 citedByCount "0" @default.
• W4312188802 crossrefType "journal-article" @default.
• W4312188802 hasAuthorship W4312188802A5007240747 @default.
• W4312188802 hasAuthorship W4312188802A5076376734 @default.
• W4312188802 hasAuthorship W4312188802A5085131425 @default.
• W4312188802 hasConcept C161790260 @default.
• W4312188802 hasConcept C178790620 @default.
• W4312188802 hasConcept C185592680 @default.
• W4312188802 hasConcept C207245611 @default.
• W4312188802 hasConcept C21951064 @default.
• W4312188802 hasConcept C2778870691 @default.
• W4312188802 hasConcept C2780073701 @default.
• W4312188802 hasConcept C2780263894 @default.
• W4312188802 hasConcept C2780471494 @default.
• W4312188802 hasConcept C2780538656 @default.
• W4312188802 hasConcept C2781076698 @default.
• W4312188802 hasConcept C539932907 @default.
• W4312188802 hasConceptScore W4312188802C161790260 @default.
• W4312188802 hasConceptScore W4312188802C178790620 @default.
• W4312188802 hasConceptScore W4312188802C185592680 @default.
• W4312188802 hasConceptScore W4312188802C207245611 @default.
• W4312188802 hasConceptScore W4312188802C21951064 @default.
• W4312188802 hasConceptScore W4312188802C2778870691 @default.
• W4312188802 hasConceptScore W4312188802C2780073701 @default.
• W4312188802 hasConceptScore W4312188802C2780263894 @default.
• W4312188802 hasConceptScore W4312188802C2780471494 @default.
• W4312188802 hasConceptScore W4312188802C2780538656 @default.
• W4312188802 hasConceptScore W4312188802C2781076698 @default.
• W4312188802 hasConceptScore W4312188802C539932907 @default.
• W4312188802 hasFunder F4320329650 @default.
• W4312188802 hasIssue "19" @default.
• W4312188802 hasLocation W43121888021 @default.
• W4312188802 hasOpenAccess W4312188802 @default.
• W4312188802 hasPrimaryLocation W43121888021 @default.
• W4312188802 hasRelatedWork W126352917 @default.
• W4312188802 hasRelatedWork W1982508727 @default.
• W4312188802 hasRelatedWork W1985633291 @default.
• W4312188802 hasRelatedWork W1990491372 @default.
• W4312188802 hasRelatedWork W2003107470 @default.
• W4312188802 hasRelatedWork W2078985763 @default.
• W4312188802 hasRelatedWork W2093860530 @default.
• W4312188802 hasRelatedWork W2158279933 @default.
• W4312188802 hasRelatedWork W2423522576 @default.
• W4312188802 hasRelatedWork W3029570087 @default.
• W4312188802 hasVolume "26" @default.
• W4312188802 isParatext "false" @default.
• W4312188802 isRetracted "false" @default.
• W4312188802 workType "article" @default.