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- W4312194514 endingPage "16066" @default.
- W4312194514 startingPage "16066" @default.
- W4312194514 abstract "Seawater pH and carbonate saturation are predicted to decrease dramatically by the end of the century. This process, designated ocean acidification (OA), threatens economically and ecologically important marine calcifiers, including the northern quahog (Mercenaria mercenaria). While many studies have demonstrated the adverse impacts of OA on bivalves, much less is known about mechanisms of resilience and adaptive strategies. Here, we examined clam responses to OA by evaluating cellular (hemocyte activities) and molecular (high-throughput proteomics, RNASeq) changes in hemolymph and extrapallial fluid (EPF-the site of biomineralization located between the mantle and the shell) in M. mercenaria continuously exposed to acidified (pH ~7.3; pCO2 ~2700 ppm) and normal conditions (pH ~8.1; pCO2 ~600 ppm) for one year. The extracellular pH of EPF and hemolymph (~7.5) was significantly higher than that of the external acidified seawater (~7.3). Under OA conditions, granulocytes (a sub-population of hemocytes important for biomineralization) were able to increase intracellular pH (by 54% in EPF and 79% in hemolymph) and calcium content (by 56% in hemolymph). The increased pH of EPF and hemolymph from clams exposed to high pCO2 was associated with the overexpression of genes (at both the mRNA and protein levels) related to biomineralization, acid-base balance, and calcium homeostasis, suggesting that clams can use corrective mechanisms to mitigate the negative impact of OA." @default.
- W4312194514 created "2023-01-04" @default.
- W4312194514 creator A5007885569 @default.
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- W4312194514 creator A5039519693 @default.
- W4312194514 creator A5051469283 @default.
- W4312194514 creator A5072472429 @default.
- W4312194514 date "2022-12-16" @default.
- W4312194514 modified "2023-10-14" @default.
- W4312194514 title "Proteomic and Transcriptomic Responses Enable Clams to Correct the pH of Calcifying Fluids and Sustain Biomineralization in Acidified Environments" @default.
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- W4312194514 doi "https://doi.org/10.3390/ijms232416066" @default.
- W4312194514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36555707" @default.
- W4312194514 hasPublicationYear "2022" @default.
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