Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312194737> ?p ?o ?g. }
- W4312194737 abstract "Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer's disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI models present with cellular metabolic alterations and modulated cleavage of amyloid precursor protein (APP). Specifically, AD and TBI tissues display increases in amyloid-β as well as its precursor, the APP C-terminal fragment of 99 a.a. (C99). Our recent data in cell models of AD indicate that C99, due to its affinity for cholesterol, induces the formation of transient lipid raft domains in the ER known as mitochondria-associated endoplasmic reticulum (ER) membranes (MAM domains). The formation of these domains recruits and activates specific lipid metabolic enzymes that regulate cellular cholesterol trafficking and sphingolipid turnover. Increased C99 levels in AD cell models promote MAM formation and significantly modulate cellular lipid homeostasis. Here, these phenotypes were recapitulated in the controlled cortical impact (CCI) model of TBI in adult mice. Specifically, the injured cortex and hippocampus displayed significant increases in C99 and MAM activity, as measured by phospholipid synthesis, sphingomyelinase activity and cholesterol turnover. In addition, our cell type-specific lipidomics analyses revealed significant changes in microglial lipid composition that are consistent with the observed alterations in MAM-resident enzymes. Altogether, we propose that alterations in the regulation of MAM and relevant lipid metabolic pathways could contribute to the epidemiological connection between TBI and AD." @default.
- W4312194737 created "2023-01-04" @default.
- W4312194737 creator A5001139699 @default.
- W4312194737 creator A5026168752 @default.
- W4312194737 creator A5029937904 @default.
- W4312194737 creator A5033777911 @default.
- W4312194737 creator A5051962816 @default.
- W4312194737 creator A5059089783 @default.
- W4312194737 creator A5059258324 @default.
- W4312194737 creator A5061093681 @default.
- W4312194737 creator A5074480078 @default.
- W4312194737 creator A5081000965 @default.
- W4312194737 creator A5081170581 @default.
- W4312194737 creator A5083891032 @default.
- W4312194737 creator A5086037006 @default.
- W4312194737 creator A5091281126 @default.
- W4312194737 date "2022-12-26" @default.
- W4312194737 modified "2023-10-12" @default.
- W4312194737 title "Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury" @default.
- W4312194737 cites W1484298026 @default.
- W4312194737 cites W1504600256 @default.
- W4312194737 cites W1530283338 @default.
- W4312194737 cites W1532356318 @default.
- W4312194737 cites W1562457256 @default.
- W4312194737 cites W1578695981 @default.
- W4312194737 cites W1605902541 @default.
- W4312194737 cites W1693567495 @default.
- W4312194737 cites W1918709096 @default.
- W4312194737 cites W1964574311 @default.
- W4312194737 cites W1965918817 @default.
- W4312194737 cites W1971213127 @default.
- W4312194737 cites W1974511187 @default.
- W4312194737 cites W1980330384 @default.
- W4312194737 cites W1981287677 @default.
- W4312194737 cites W1981956598 @default.
- W4312194737 cites W1991321700 @default.
- W4312194737 cites W1991893128 @default.
- W4312194737 cites W1993220836 @default.
- W4312194737 cites W1999857229 @default.
- W4312194737 cites W2001402586 @default.
- W4312194737 cites W2002251052 @default.
- W4312194737 cites W2005926152 @default.
- W4312194737 cites W2011949052 @default.
- W4312194737 cites W2013312860 @default.
- W4312194737 cites W2014671368 @default.
- W4312194737 cites W2015063205 @default.
- W4312194737 cites W2020585666 @default.
- W4312194737 cites W2029446702 @default.
- W4312194737 cites W2031846075 @default.
- W4312194737 cites W2038326581 @default.
- W4312194737 cites W2038393971 @default.
- W4312194737 cites W2040664092 @default.
- W4312194737 cites W2041802741 @default.
- W4312194737 cites W2041953844 @default.
- W4312194737 cites W2043969447 @default.
- W4312194737 cites W2045333877 @default.
- W4312194737 cites W2050669612 @default.
- W4312194737 cites W2054275187 @default.
- W4312194737 cites W2059089835 @default.
- W4312194737 cites W2061123524 @default.
- W4312194737 cites W2065904280 @default.
- W4312194737 cites W2067003329 @default.
- W4312194737 cites W2067361016 @default.
- W4312194737 cites W2071145481 @default.
- W4312194737 cites W2071172843 @default.
- W4312194737 cites W2073009405 @default.
- W4312194737 cites W2076386951 @default.
- W4312194737 cites W2077722171 @default.
- W4312194737 cites W2078549633 @default.
- W4312194737 cites W2078565488 @default.
- W4312194737 cites W2081808464 @default.
- W4312194737 cites W2082429191 @default.
- W4312194737 cites W2085374176 @default.
- W4312194737 cites W2090982126 @default.
- W4312194737 cites W2091485657 @default.
- W4312194737 cites W2093157615 @default.
- W4312194737 cites W2093643838 @default.
- W4312194737 cites W2098329073 @default.
- W4312194737 cites W2101828725 @default.
- W4312194737 cites W2106501833 @default.
- W4312194737 cites W2110374590 @default.
- W4312194737 cites W2112323767 @default.
- W4312194737 cites W2117886681 @default.
- W4312194737 cites W2123436811 @default.
- W4312194737 cites W2125948731 @default.
- W4312194737 cites W2134907293 @default.
- W4312194737 cites W2136321913 @default.
- W4312194737 cites W2146156622 @default.
- W4312194737 cites W2146544786 @default.
- W4312194737 cites W2148957789 @default.
- W4312194737 cites W2156779372 @default.
- W4312194737 cites W2158435581 @default.
- W4312194737 cites W2163181319 @default.
- W4312194737 cites W2166131107 @default.
- W4312194737 cites W2166940533 @default.
- W4312194737 cites W2168079862 @default.
- W4312194737 cites W2254593697 @default.
- W4312194737 cites W2258234778 @default.
- W4312194737 cites W2290337523 @default.
- W4312194737 cites W2302280739 @default.