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- W4312194927 startingPage "16115" @default.
- W4312194927 abstract "Pyroptosis is an active and ordered form of programmed cell death. The signaling pathways of pyroptosis are mainly divided into canonical pathways mediated by caspase-1 and noncanonical pathways mediated by caspase-11. Cell pyroptosis is characterized by the activation of inflammatory caspases (mainly caspase-1, 4, 5, 11) and cleavage of various members of the Gasdermin family to form membrane perforation components, leading to cell membrane rupture, inflammatory mediators release, and cell death. Moderate pyroptosis is an innate immune response that fights against infection and plays an important role in the occurrence and development of the normal function of the immune system. However, excessive pyroptosis occurs and leads to immune disorders in many pathological conditions. Based on canonical pathways, research on pyroptosis regulation has demonstrated several pyroptotic inhibitors, including small-molecule drugs, natural products, and formulations of traditional Chinese medicines. In this paper, we review the characteristics and molecular mechanisms of pyroptosis, summarize inhibitors of pyroptosis, and propound that herbal medicines should be a focus on the research and development for pyroptosis blockers." @default.
- W4312194927 created "2023-01-04" @default.
- W4312194927 creator A5024385900 @default.
- W4312194927 creator A5085336584 @default.
- W4312194927 creator A5035329548 @default.
- W4312194927 date "2022-12-17" @default.
- W4312194927 modified "2023-10-18" @default.
- W4312194927 title "Molecular Characteristics of Cell Pyroptosis and Its Inhibitors: A Review of Activation, Regulation, and Inhibitors" @default.
- W4312194927 cites W1529674879 @default.
- W4312194927 cites W1571910978 @default.
- W4312194927 cites W1864325817 @default.
- W4312194927 cites W1882905539 @default.
- W4312194927 cites W1904683780 @default.
- W4312194927 cites W1966176339 @default.
- W4312194927 cites W1970242970 @default.
- W4312194927 cites W1974744480 @default.
- W4312194927 cites W197615574 @default.
- W4312194927 cites W1984338631 @default.
- W4312194927 cites W1988518686 @default.
- W4312194927 cites W1989047636 @default.
- W4312194927 cites W1997614596 @default.
- W4312194927 cites W2001420437 @default.
- W4312194927 cites W2001979726 @default.
- W4312194927 cites W2005273684 @default.
- W4312194927 cites W2010243701 @default.
- W4312194927 cites W2012524417 @default.
- W4312194927 cites W2018334071 @default.
- W4312194927 cites W2024105041 @default.
- W4312194927 cites W2026400708 @default.
- W4312194927 cites W2030786210 @default.
- W4312194927 cites W2042506368 @default.
- W4312194927 cites W2044744453 @default.
- W4312194927 cites W2051652709 @default.
- W4312194927 cites W2051658957 @default.
- W4312194927 cites W2052895824 @default.
- W4312194927 cites W2056155809 @default.
- W4312194927 cites W2057039052 @default.
- W4312194927 cites W2062014088 @default.
- W4312194927 cites W2068619092 @default.
- W4312194927 cites W2070020247 @default.
- W4312194927 cites W2072874642 @default.
- W4312194927 cites W2074747472 @default.
- W4312194927 cites W2078850432 @default.
- W4312194927 cites W2080827095 @default.
- W4312194927 cites W2082653928 @default.
- W4312194927 cites W2084708403 @default.
- W4312194927 cites W2087092800 @default.
- W4312194927 cites W2088164523 @default.
- W4312194927 cites W2095404434 @default.
- W4312194927 cites W2098814976 @default.
- W4312194927 cites W2101006281 @default.
- W4312194927 cites W2110252008 @default.
- W4312194927 cites W2113839377 @default.
- W4312194927 cites W2114266096 @default.
- W4312194927 cites W2114769428 @default.
- W4312194927 cites W2117820574 @default.
- W4312194927 cites W2118403357 @default.
- W4312194927 cites W2118800225 @default.
- W4312194927 cites W2124598613 @default.
- W4312194927 cites W2127314810 @default.
- W4312194927 cites W2130940574 @default.
- W4312194927 cites W2134007048 @default.
- W4312194927 cites W2134735862 @default.
- W4312194927 cites W2143102054 @default.
- W4312194927 cites W2145866317 @default.
- W4312194927 cites W2156072340 @default.
- W4312194927 cites W2159590959 @default.
- W4312194927 cites W2162362258 @default.
- W4312194927 cites W2166956701 @default.
- W4312194927 cites W2170226518 @default.
- W4312194927 cites W2170936782 @default.
- W4312194927 cites W2175794645 @default.
- W4312194927 cites W2254807163 @default.
- W4312194927 cites W2269721101 @default.
- W4312194927 cites W2328275151 @default.
- W4312194927 cites W2418806051 @default.
- W4312194927 cites W2431987552 @default.
- W4312194927 cites W2461915818 @default.
- W4312194927 cites W2462773201 @default.
- W4312194927 cites W2486445835 @default.
- W4312194927 cites W2517997111 @default.
- W4312194927 cites W2518557919 @default.
- W4312194927 cites W2522054313 @default.
- W4312194927 cites W2548961292 @default.
- W4312194927 cites W2551749159 @default.
- W4312194927 cites W2560280719 @default.
- W4312194927 cites W2560541542 @default.
- W4312194927 cites W2583964565 @default.
- W4312194927 cites W2605402511 @default.
- W4312194927 cites W2608233061 @default.
- W4312194927 cites W2734317528 @default.
- W4312194927 cites W2735069880 @default.
- W4312194927 cites W2766642320 @default.
- W4312194927 cites W2769031338 @default.
- W4312194927 cites W2769976324 @default.
- W4312194927 cites W2790572647 @default.
- W4312194927 cites W2791444686 @default.
- W4312194927 cites W2791711864 @default.