Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312196377> ?p ?o ?g. }
- W4312196377 endingPage "2819" @default.
- W4312196377 startingPage "2819" @default.
- W4312196377 abstract "HIV vaccine mediated efficacy, using an expanded live attenuated recombinant varicella virus-vectored SIV rSVV-SIVgag/env vaccine prime with adjuvanted SIV-Env and SIV-Gag protein boosts, was evaluated in a female rhesus macaques (RM) model against repeated intravaginal SIV challenges. Vaccination induced anti-SIV IgG responses and neutralizing antibodies were found in all vaccinated RMs. Three of the eight vaccinated RM remained uninfected (vaccinated and protected, VP) after 13 repeated challenges with the pathogenic SIVmac251-CX-1. The remaining five vaccinated and infected (VI) macaques had significantly reduced plasma viral loads compared with the infected controls (IC). A significant increase in systemic central memory CD4+ T cells and mucosal CD8+ effector memory T-cell responses was detected in vaccinated RMs compared to controls. Variability in lymph node SIV-Gag and Env specific CD4+ and CD8+ T cell cytokine responses were detected in the VI RMs while all three VP RMs had more durable cytokine responses following vaccination and prior to challenge. VI RMs demonstrated predominately SIV-specific monofunctional cytokine responses while the VP RMs generated polyfunctional cytokine responses. This study demonstrates that varicella virus-vectored SIV vaccination with protein boosts induces a 37.5% efficacy rate against pathogenic SIV challenge by generating mucosal memory, virus specific neutralizing antibodies, binding antibodies, and polyfunctional T-cell responses." @default.
- W4312196377 created "2023-01-04" @default.
- W4312196377 creator A5004036928 @default.
- W4312196377 creator A5004950069 @default.
- W4312196377 creator A5015270385 @default.
- W4312196377 creator A5019546980 @default.
- W4312196377 creator A5022626757 @default.
- W4312196377 creator A5023390986 @default.
- W4312196377 creator A5033852647 @default.
- W4312196377 creator A5034536696 @default.
- W4312196377 creator A5037980294 @default.
- W4312196377 creator A5044636000 @default.
- W4312196377 creator A5050385001 @default.
- W4312196377 creator A5051110753 @default.
- W4312196377 creator A5052768263 @default.
- W4312196377 creator A5056602559 @default.
- W4312196377 creator A5056851037 @default.
- W4312196377 creator A5075274352 @default.
- W4312196377 creator A5076860070 @default.
- W4312196377 creator A5081401602 @default.
- W4312196377 creator A5081530445 @default.
- W4312196377 creator A5090531490 @default.
- W4312196377 date "2022-12-17" @default.
- W4312196377 modified "2023-09-30" @default.
- W4312196377 title "Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques" @default.
- W4312196377 cites W139195881 @default.
- W4312196377 cites W1582246051 @default.
- W4312196377 cites W1586397064 @default.
- W4312196377 cites W1608385764 @default.
- W4312196377 cites W1695454552 @default.
- W4312196377 cites W1954146347 @default.
- W4312196377 cites W1966184176 @default.
- W4312196377 cites W1969295484 @default.
- W4312196377 cites W1974433492 @default.
- W4312196377 cites W1978896600 @default.
- W4312196377 cites W1979728905 @default.
- W4312196377 cites W1994756445 @default.
- W4312196377 cites W2004045952 @default.
- W4312196377 cites W2021550859 @default.
- W4312196377 cites W2029440192 @default.
- W4312196377 cites W2045108087 @default.
- W4312196377 cites W2049921779 @default.
- W4312196377 cites W2052260102 @default.
- W4312196377 cites W2054248993 @default.
- W4312196377 cites W2063834545 @default.
- W4312196377 cites W2065969191 @default.
- W4312196377 cites W2082281606 @default.
- W4312196377 cites W2088117965 @default.
- W4312196377 cites W2088741812 @default.
- W4312196377 cites W2107479692 @default.
- W4312196377 cites W2108743658 @default.
- W4312196377 cites W2111098656 @default.
- W4312196377 cites W2112225216 @default.
- W4312196377 cites W2114797085 @default.
- W4312196377 cites W2118790593 @default.
- W4312196377 cites W2122531531 @default.
- W4312196377 cites W2128124419 @default.
- W4312196377 cites W2130034923 @default.
- W4312196377 cites W2135304312 @default.
- W4312196377 cites W2135843416 @default.
- W4312196377 cites W2141921379 @default.
- W4312196377 cites W2143421242 @default.
- W4312196377 cites W2143460513 @default.
- W4312196377 cites W2144059995 @default.
- W4312196377 cites W2148873145 @default.
- W4312196377 cites W2152048324 @default.
- W4312196377 cites W2170904230 @default.
- W4312196377 cites W2281676691 @default.
- W4312196377 cites W2329910582 @default.
- W4312196377 cites W2558624570 @default.
- W4312196377 cites W2733120775 @default.
- W4312196377 cites W2793560382 @default.
- W4312196377 cites W2902867755 @default.
- W4312196377 cites W2943265501 @default.
- W4312196377 cites W2944064358 @default.
- W4312196377 cites W2973305373 @default.
- W4312196377 cites W3011023976 @default.
- W4312196377 cites W3011184158 @default.
- W4312196377 cites W30316958 @default.
- W4312196377 cites W3112209524 @default.
- W4312196377 cites W3128190569 @default.
- W4312196377 cites W3158010736 @default.
- W4312196377 cites W3213041755 @default.
- W4312196377 cites W4221083848 @default.
- W4312196377 doi "https://doi.org/10.3390/v14122819" @default.
- W4312196377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36560823" @default.
- W4312196377 hasPublicationYear "2022" @default.
- W4312196377 type Work @default.
- W4312196377 citedByCount "0" @default.
- W4312196377 crossrefType "journal-article" @default.
- W4312196377 hasAuthorship W4312196377A5004036928 @default.
- W4312196377 hasAuthorship W4312196377A5004950069 @default.
- W4312196377 hasAuthorship W4312196377A5015270385 @default.
- W4312196377 hasAuthorship W4312196377A5019546980 @default.
- W4312196377 hasAuthorship W4312196377A5022626757 @default.
- W4312196377 hasAuthorship W4312196377A5023390986 @default.
- W4312196377 hasAuthorship W4312196377A5033852647 @default.
- W4312196377 hasAuthorship W4312196377A5034536696 @default.