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- W431219692 abstract "Hepatic microsomal enzyme systems can be activated by pretreatment with phenobarbital, other barbiturates, ddt, and many other drugs. Contrarily, another compound such as skf 525-a, ethionine, and puromycin can inhibit the same enzymatic mechanisms. The sleep-time periods of albino rats produced by pentobarbital, thiopental, zoxazolamine, ci-581, diazepam, and gamma-hydroxybutyrate were significantly shortened by previous administration of phenobarbital twice daily for four days. However, the duration of action of the same anaesthetics was significantly prolonged when the animals were “pretreated” by the administration of skf 525-a, an inhibiter of liver microsomal enzymes." @default.
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- W431219692 date "1969-11-01" @default.
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- W431219692 title "Influence of enzyme induction on the sleeping time of rats" @default.
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- W431219692 doi "https://doi.org/10.1007/bf03004547" @default.
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