FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312198055> ?p ?o ?g. }

• W4312198055 abstract "Abstract Aim To evaluate the real‐world usage pattern and factors associated with the effectiveness of regorafenib in patients with metastatic colorectal cancer (mCRC). Methods This retrospective study analyzed data for 209 patients with mCRC treated with regorafenib as third or later line of therapy. TheKaplan–Meier method was used to draw the survival curves. Cox proportional hazard regression models were used to analyze the prognostic value for overall survival (OS). Results Of 209 patients, 156 (75%) were treated with regorafenib, and 53 (25%) were given regorafenib combined with programmed cell death‐1 (PD‐1) inhibitors. About 182 (87%) patients had a dose record of regorafenib. The initial daily doses of regorafenib were 160, 120, 80, and 40 mg, accounting for 29%, 17%, 48%, and 6% of patients, respectively. The median follow‐up time was 11.3 months, and the median OS was 12.0 months (95% CI: 9.7–14.3). Patients treated with PD‐1 inhibitors plus regorafenib had a longer OS than the non‐PD‐1 group (13.5 vs. 10.1 months, hazard ratio [HR] = .534, 95% CI: .325–.879; p = .014). A total of 49 patients with microsatellite stable or mismatch repair‐proficient genotype treated with PD‐1 inhibitors plus regorafenib had a longer OS than the non‐PD‐1 group (13.5 vs. 9.7 months; HR = .563, p = .027). The median OS of patients continuing treatment with regorafenib after progression ( n = 19, with five patients receiving additional immunotherapy) was marginally longer than patients discontinuing regorafenib after progression (12.7 vs. 11.9 months, p = .425) observed in a smaller cohort. Conclusion In real‐world practice, patients with mCRC in whom standard regimens had failed have a good survival benefit with regorafenib. Combination with PD‐1 inhibitor may further prolong survival of the patients." @default.
• W4312198055 created "2023-01-04" @default.
• W4312198055 creator A5008405013 @default.
• W4312198055 creator A5021540700 @default.
• W4312198055 creator A5050027748 @default.
• W4312198055 creator A5078939982 @default.
• W4312198055 creator A5086231834 @default.
• W4312198055 creator A5091341521 @default.
• W4312198055 date "2022-12-26" @default.
• W4312198055 modified "2023-09-26" @default.
• W4312198055 title "Real‐world effectiveness of regorafenib in the treatment of patients with metastatic colorectal cancer: A retrospective, observational study" @default.
• W4312198055 cites W1940241680 @default.
• W4312198055 cites W2054301472 @default.
• W4312198055 cites W2111851685 @default.
• W4312198055 cites W2113082145 @default.
• W4312198055 cites W2133811732 @default.
• W4312198055 cites W2147834058 @default.
• W4312198055 cites W2265419075 @default.
• W4312198055 cites W2467206133 @default.
• W4312198055 cites W2470575266 @default.
• W4312198055 cites W2542519792 @default.
• W4312198055 cites W2611025690 @default.
• W4312198055 cites W2789525724 @default.
• W4312198055 cites W2791328450 @default.
• W4312198055 cites W2811168026 @default.
• W4312198055 cites W2889646458 @default.
• W4312198055 cites W2894099206 @default.
• W4312198055 cites W2933419869 @default.
• W4312198055 cites W2949144648 @default.
• W4312198055 cites W2954373381 @default.
• W4312198055 cites W2987121958 @default.
• W4312198055 cites W3006728494 @default.
• W4312198055 cites W3020689019 @default.
• W4312198055 cites W3140137835 @default.
• W4312198055 cites W3165945214 @default.
• W4312198055 cites W3169075861 @default.
• W4312198055 cites W3184046266 @default.
• W4312198055 cites W4255291191 @default.
• W4312198055 doi "https://doi.org/10.1111/ajco.13909" @default.
• W4312198055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36572661" @default.
• W4312198055 hasPublicationYear "2022" @default.
• W4312198055 type Work @default.
• W4312198055 citedByCount "0" @default.
• W4312198055 crossrefType "journal-article" @default.
• W4312198055 hasAuthorship W4312198055A5008405013 @default.
• W4312198055 hasAuthorship W4312198055A5021540700 @default.
• W4312198055 hasAuthorship W4312198055A5050027748 @default.
• W4312198055 hasAuthorship W4312198055A5078939982 @default.
• W4312198055 hasAuthorship W4312198055A5086231834 @default.
• W4312198055 hasAuthorship W4312198055A5091341521 @default.
• W4312198055 hasBestOaLocation W43121980551 @default.
• W4312198055 hasConcept C121608353 @default.
• W4312198055 hasConcept C126322002 @default.
• W4312198055 hasConcept C141071460 @default.
• W4312198055 hasConcept C143998085 @default.
• W4312198055 hasConcept C167135981 @default.
• W4312198055 hasConcept C207103383 @default.
• W4312198055 hasConcept C2776248978 @default.
• W4312198055 hasConcept C44249647 @default.
• W4312198055 hasConcept C50382708 @default.
• W4312198055 hasConcept C526805850 @default.
• W4312198055 hasConcept C71924100 @default.
• W4312198055 hasConceptScore W4312198055C121608353 @default.
• W4312198055 hasConceptScore W4312198055C126322002 @default.
• W4312198055 hasConceptScore W4312198055C141071460 @default.
• W4312198055 hasConceptScore W4312198055C143998085 @default.
• W4312198055 hasConceptScore W4312198055C167135981 @default.
• W4312198055 hasConceptScore W4312198055C207103383 @default.
• W4312198055 hasConceptScore W4312198055C2776248978 @default.
• W4312198055 hasConceptScore W4312198055C44249647 @default.
• W4312198055 hasConceptScore W4312198055C50382708 @default.
• W4312198055 hasConceptScore W4312198055C526805850 @default.
• W4312198055 hasConceptScore W4312198055C71924100 @default.
• W4312198055 hasLocation W43121980551 @default.
• W4312198055 hasLocation W43121980552 @default.
• W4312198055 hasOpenAccess W4312198055 @default.
• W4312198055 hasPrimaryLocation W43121980551 @default.
• W4312198055 hasRelatedWork W1914096367 @default.
• W4312198055 hasRelatedWork W1964399992 @default.
• W4312198055 hasRelatedWork W2056185445 @default.
• W4312198055 hasRelatedWork W2089110416 @default.
• W4312198055 hasRelatedWork W2542604898 @default.
• W4312198055 hasRelatedWork W2606624379 @default.
• W4312198055 hasRelatedWork W2750934333 @default.
• W4312198055 hasRelatedWork W2922035683 @default.
• W4312198055 hasRelatedWork W3154676755 @default.
• W4312198055 hasRelatedWork W3208063913 @default.
• W4312198055 isParatext "false" @default.
• W4312198055 isRetracted "false" @default.
• W4312198055 workType "article" @default.