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- W4312198210 abstract "Summary Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer’s disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, while β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and Aβ intersect intracellularly. We show that internalized astrocytic ApoE localizes mostly to lysosomes in neuroblastoma cells and astrocytes, while in neurons it preferentially localizes to endosomes-autophagosomes of neurites. In AD transgenic neurons, astrocyte-derived ApoE intersects intracellularly with amyloid precursor protein (APP)/Aβ. Moreover, ApoE4 increases the levels of endogenous and internalized Aβ 42 in neurons. Taken together, we demonstrate differential localization of ApoE in neurons, astrocytes and neuron-like cells, and show that internalized ApoE intersects with APP/Aβ in neurons, which may be of considerable relevance to AD." @default.
- W4312198210 created "2023-01-04" @default.
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- W4312198210 date "2022-12-13" @default.
- W4312198210 modified "2023-10-12" @default.
- W4312198210 title "Apolipoprotein E intersects with amyloid-β within neurons" @default.
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- W4312198210 doi "https://doi.org/10.1101/2022.12.13.520238" @default.
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