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- W4312198366 abstract "ABSTRACT While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ∼one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly booster vaccine, and as a primary vaccine for pediatric use including in infants." @default.
- W4312198366 created "2023-01-04" @default.
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- W4312198366 date "2022-12-26" @default.
- W4312198366 modified "2023-10-08" @default.
- W4312198366 title "A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates" @default.
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- W4312198366 doi "https://doi.org/10.1101/2022.12.25.521784" @default.
- W4312198366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597527" @default.
- W4312198366 hasPublicationYear "2022" @default.
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