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- W4312201460 abstract "DNAzyme-based sensors remain at the forefront of metal-ion imaging efforts, but most lack the subcellular precision necessary to their applications in specific organelles. Here, we seek to overcome this limitation by presenting a DNAzyme-based biosensor technology for spatiotemporally controlled imaging of metal ions in mitochondria. A DNA nanodevice was constructed by integrating an optically activatable DNAzyme sensor and an upconversion nanoparticle with an organelle-targeting signal. We exemplify that this approach allows for mitochondria-specific imaging of Zn2+ in living cells in a near-infrared light-controlled manner. Based on this, the system is used for the monitoring of mitochondrial Zn2+ during drug treatment in a cellular model of ischemia insult. Furthermore, the DNA nanodevice is employed to assess dynamic Zn2+ change and pharmacological interventions in an injury cell model of Zn2+ toxicity. This method paves the way for engineering of DNAzyme sensors to investigate the pathophysiological roles of metal ions at the subcellular level." @default.
- W4312201460 created "2023-01-04" @default.
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- W4312201460 creator A5060957631 @default.
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- W4312201460 creator A5091410485 @default.
- W4312201460 date "2022-12-27" @default.
- W4312201460 modified "2023-10-11" @default.
- W4312201460 title "Modular Engineering of DNAzyme-Based Sensors for Spatioselective Imaging of Metal Ions in Mitochondria" @default.
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- W4312201460 doi "https://doi.org/10.1021/jacs.2c11081" @default.
- W4312201460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36573341" @default.
- W4312201460 hasPublicationYear "2022" @default.
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