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- W4312204037 endingPage "4089.e6" @default.
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- W4312204037 abstract "How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and endothelial cells (ECs), necessary for the coordinated development of MNs. By analyzing cell-to-cell interaction profiles of the mouse developing spinal cord, we uncovered semaphorin 3C (Sema3C) and PlexinD1 as a communication axis between MNs and ECs. Using cell-specific knockout mice and in vitro assays, we demonstrate that removal of Sema3C in MNs, or its receptor PlexinD1 in ECs, results in premature and aberrant vascularization of MN columns. Those vascular defects impair MN axon exit from the spinal cord. Impaired PlexinD1 signaling in ECs also causes MN maturation defects at later stages. This study highlights the importance of a timely and spatially controlled communication between MNs and ECs for proper spinal cord development." @default.
- W4312204037 created "2023-01-04" @default.
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- W4312204037 date "2022-12-01" @default.
- W4312204037 modified "2023-10-16" @default.
- W4312204037 title "Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development" @default.
- W4312204037 cites W1504922538 @default.
- W4312204037 cites W1658014327 @default.
- W4312204037 cites W1964544654 @default.
- W4312204037 cites W1979586828 @default.
- W4312204037 cites W1980294445 @default.
- W4312204037 cites W1981739523 @default.
- W4312204037 cites W1987113148 @default.
- W4312204037 cites W1989981283 @default.
- W4312204037 cites W1992553297 @default.
- W4312204037 cites W1993913999 @default.
- W4312204037 cites W1993982470 @default.
- W4312204037 cites W1994912172 @default.
- W4312204037 cites W1997508706 @default.
- W4312204037 cites W2008004968 @default.
- W4312204037 cites W2009329082 @default.
- W4312204037 cites W2014562769 @default.
- W4312204037 cites W2017856054 @default.
- W4312204037 cites W2032112615 @default.
- W4312204037 cites W2032367884 @default.
- W4312204037 cites W2037921965 @default.
- W4312204037 cites W2041700814 @default.
- W4312204037 cites W2049586534 @default.
- W4312204037 cites W2052919205 @default.
- W4312204037 cites W2054101093 @default.
- W4312204037 cites W2054917924 @default.
- W4312204037 cites W2058116209 @default.
- W4312204037 cites W2064255351 @default.
- W4312204037 cites W2068488653 @default.
- W4312204037 cites W2071780639 @default.
- W4312204037 cites W2079344476 @default.
- W4312204037 cites W2079833508 @default.
- W4312204037 cites W2081235375 @default.
- W4312204037 cites W2083249373 @default.
- W4312204037 cites W2090393106 @default.
- W4312204037 cites W2091805482 @default.
- W4312204037 cites W2092641793 @default.
- W4312204037 cites W2112450500 @default.
- W4312204037 cites W2113977679 @default.
- W4312204037 cites W2115716038 @default.
- W4312204037 cites W2120335426 @default.
- W4312204037 cites W2129109253 @default.
- W4312204037 cites W2129600117 @default.
- W4312204037 cites W2133427405 @default.
- W4312204037 cites W2134598491 @default.
- W4312204037 cites W2135202732 @default.
- W4312204037 cites W2139190679 @default.
- W4312204037 cites W2153669478 @default.
- W4312204037 cites W2163409186 @default.
- W4312204037 cites W2166540950 @default.
- W4312204037 cites W2207941023 @default.
- W4312204037 cites W2279320212 @default.
- W4312204037 cites W2543042652 @default.
- W4312204037 cites W2553065093 @default.
- W4312204037 cites W2555984954 @default.
- W4312204037 cites W2571141755 @default.
- W4312204037 cites W2594165703 @default.
- W4312204037 cites W2760943838 @default.
- W4312204037 cites W2774169211 @default.
- W4312204037 cites W2797776575 @default.
- W4312204037 cites W2898312835 @default.
- W4312204037 cites W2923081206 @default.
- W4312204037 cites W2929509476 @default.
- W4312204037 cites W2951767369 @default.
- W4312204037 cites W2971266519 @default.
- W4312204037 cites W3005314662 @default.
- W4312204037 cites W3006650868 @default.
- W4312204037 cites W3014477614 @default.
- W4312204037 cites W3116809201 @default.
- W4312204037 cites W3124103630 @default.
- W4312204037 cites W3128377422 @default.
- W4312204037 cites W3132661792 @default.
- W4312204037 cites W3156847384 @default.
- W4312204037 cites W4226552259 @default.
- W4312204037 cites W4305014648 @default.
- W4312204037 cites W753758445 @default.