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- W4312205638 abstract "An increase of the click-to-release reaction rate between cleavable trans-cyclooctenes (TCO) and tetrazines would be beneficial for drug delivery applications. In this work, we developed a short and stereoselective synthesis route towards highly reactive sTCOs that serve as cleavable linkers, affording quantitative tetrazine-triggered payload release. In addition, the 5-fold more reactive sTCO exhibited the same in vivo stability as the parent TCO linker when used as antibody linker in circulation in mice." @default.
- W4312205638 created "2023-01-04" @default.
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- W4312205638 date "2022-12-27" @default.
- W4312205638 modified "2023-09-27" @default.
- W4312205638 title "A Concise Synthetic Approach to Highly Reactive Click-to-Release Trans-Cyclooctene Linkers" @default.
- W4312205638 doi "https://doi.org/10.26434/chemrxiv-2022-xrq3p" @default.
- W4312205638 hasPublicationYear "2022" @default.
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