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- W4312209752 endingPage "1190" @default.
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- W4312209752 abstract "Apoptosis-based treatment plays an important role in regulating the death of tumor cells (e.g., chemotherapy, radiotherapy, and immunotherapy). Nevertheless, cancer cells can escape surveillance from apoptosis-associated signaling by bypassing other biological pathways and thus result in considerable resistance to therapies. Significantly, ferroptosis, a newly identified type of regulated cell death that is characterized by iron-dependent and lipid peroxidation accumulation, has aroused great research interest in cancer therapy. Increasing approaches have been developed to induce ferroptosis of tumor cells, including using clinically approved drugs, experimentally used compounds, and nanomedicine formulations. More importantly, the emerging nanomedicine-based strategy has made great advances in tumor treatment because of the promising targeting efficacy and enhanced therapeutic effects. In this review, we mainly overview state-of-the-art research on nanomedicine-mediated ferroptosis targeting strategies for synergistic cancer therapies, such as immunotherapy, chemotherapy, radiotherapy, and photothermal therapy. The potential targeting mechanism of nanomedicine for ferroptosis induction was also included. Finally, the future development of nanomedicine in the field of ferroptosis-based cell death in tumor treatment will be envisioned, aiming to provide new insight for tumor treatment in the clinic." @default.
- W4312209752 created "2023-01-04" @default.
- W4312209752 creator A5008008825 @default.
- W4312209752 creator A5008408701 @default.
- W4312209752 creator A5041507918 @default.
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- W4312209752 creator A5051464217 @default.
- W4312209752 creator A5063610143 @default.
- W4312209752 creator A5084027999 @default.
- W4312209752 date "2023-01-01" @default.
- W4312209752 modified "2023-10-17" @default.
- W4312209752 title "Nanomedicine-mediated ferroptosis targeting strategies for synergistic cancer therapy" @default.
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