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• W4312210168 endingPage "471" @default.
• W4312210168 startingPage "461" @default.
• W4312210168 abstract "Introduction Glucocorticoids (GC) have been part of the standard treatment of anti-neutrophil cytoplasm autoantibodies (ANCA)-associated vasculitides (AAV) for more than 60 years. Various therapeutic advances have occurred over the past 2 decades and led to a significant reduction of GC exposure, but most patients still have to suffer from complications of GC, including infections, metabolic abnormalities, and cardiovascular morbidity. In 2007, activation of the complement pathway was demonstrated to play a role in the pathogenesis of AAV. Avacopan, an oral competitive inhibitor of the C5a receptor (C5aR1, CD88), was then developed, with an additional aim to decrease the use of GC.Areas covered In this article, we briefly summarize the rationale for targeting the complement pathway in AAV, and review relevant findings from pre-clinical, phase I, II, and III studies, subsequent and more recent case reports and series on the efficacy and safety of avacopan.Expert opinion Based on the results of these studies, avacopan was approved in most countries since late 2021, as an adjunctive induction treatment for patients with AAV. Several newer questions now are pending answers, including as to how avacopan should be used in real-world practice, beyond how it was given in the original clinical trials." @default.
• W4312210168 created "2023-01-04" @default.
• W4312210168 creator A5001643187 @default.
• W4312210168 creator A5072534028 @default.
• W4312210168 creator A5075309120 @default.
• W4312210168 date "2022-12-26" @default.
• W4312210168 modified "2023-10-14" @default.
• W4312210168 title "Avacopan for the treatment of ANCA-associated vasculitis: an update" @default.
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• W4312210168 doi "https://doi.org/10.1080/1744666x.2023.2162041" @default.
• W4312210168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36545762" @default.
• W4312210168 hasPublicationYear "2022" @default.
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