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- W4312211881 abstract "How to set up a placebo control scientifically and effectively is a problem in clinical research on acupuncture therapy. In 2020, the UK National Institute of Health Research established a standardized methodological framework DITTO, that is, DeconstructIdentifyTake outThink and Optimize to standardize the setting of invasive console-control intervention. Acupuncture therapy theoretically belongs to the category of invasive therapeutic intervention, and the percutaneous puncture therapy was also considered when the DITTO framework was developed. Therefore, this framework can be applied to clinical research of acupuncture, and may provide a reference for the appropriate setting of simulated acupuncture. In this article, we introduce the formulation process and main contents of the DITTO framework, and analyze the adjustments needed to be made and possible problems encountered in the application of each part of the framework in acupuncture clinical research through medical cases. The DITTO framework can guide and standardize the design of mock acupuncture control in acupuncture clinical research to a certain extent, which is conducive to finding a more suitable implementation method of mock acupuncture, thus promoting the improvement of the quality of acupuncture clinical research. However, because there is no precedent in the field of acupuncture in traditional Chinese medicine, further research is needed in the future practical application so that it can be better combined with the characteristics of acupuncture and the purpose of clinical research.如何科学有效地设置安慰对照是针刺临床研究的难题。2020年,英国国立卫生研究所制定了一套由“Deconstruct”“Identify”“Take out”“Think”“Optimize”5个环节构成的标准化方法学框架(DITTO框架)以规范侵入性安慰对照干预的设置。针刺在理论上属于侵入性治疗干预的范畴,在DITTO框架制定时也考虑了经皮穿刺疗法。因此,该框架可以尝试应用在针刺临床研究中,为适宜的模拟针刺对照设置提供参考。本文介绍了DITTO框架的制定过程与主要内容,并通过案例对框架各部分在针刺临床研究应用时需要做出的调整以及可能遇到的问题进行了分析。DITTO框架可以在一定程度上指导和规范针刺临床研究中模拟针刺对照的设计,有利于找到更为适宜的模拟针刺实施方式,从而促进针刺临床研究质量的提升。但由于尚无在中医针刺领域应用的先例,在今后的实际应用中还需要进一步研究,使其能更好地与针刺特点及临床研究的目的相结合。." @default.
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- W4312211881 date "2022-12-25" @default.
- W4312211881 modified "2023-10-18" @default.
- W4312211881 title "[Enlightenments of DITTO framework and its application for setting up mock acupuncture in clinical research]." @default.
- W4312211881 doi "https://doi.org/10.13702/j.1000-0607.20211082" @default.
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