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- W4312216219 endingPage "6866" @default.
- W4312216219 startingPage "6846" @default.
- W4312216219 abstract "Bile acids (BAs) serve as physiological detergents that enable the intestinal absorption and transportation of nutrients, lipids and vitamins. BAs are primarily produced by humans to catabolize cholesterol and play crucial roles in gut metabolism, microbiota habitat regulation and cell signaling. BA-activated nuclear receptors regulate the enterohepatic circulation of BAs which play a role in energy, lipid, glucose, and drug metabolism. The gut microbiota plays an essential role in the biotransformation of BAs and regulates BAs composition and metabolism. Therefore, altered gut microbial and BAs activity can affect human metabolism and thus result in the alteration of metabolic pathways and the occurrence of metabolic diseases/syndromes, such as diabetes mellitus, obesity/hypercholesterolemia, and cardiovascular diseases. BAs and their metabolites are used to treat altered gut microbiota and metabolic diseases. This review explores the increasing body of evidence that links alterations of gut microbial activity and BAs with the pathogenesis of metabolic diseases. Moreover, we summarize existing research on gut microbes and BAs in relation to intracellular pathways pertinent to metabolic disorders. Finally, we discuss how therapeutic interventions using BAs can facilitate microbiome functioning and ease metabolic diseases." @default.
- W4312216219 created "2023-01-04" @default.
- W4312216219 creator A5019884903 @default.
- W4312216219 creator A5050733578 @default.
- W4312216219 creator A5060838325 @default.
- W4312216219 creator A5072052283 @default.
- W4312216219 date "2022-12-28" @default.
- W4312216219 modified "2023-10-18" @default.
- W4312216219 title "Bile acids and microbes in metabolic disease" @default.
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