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• W4312218877 abstract "Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies cannot avoid confounding factors from interventions, human eye composition and structure are unique, thus, eye disease pathogenesis, which greatly impairs quality of life and visual health, remains to be fully explored. Notwithstanding, inheritance has had a vital role in ophthalmic disease. Mendelian randomization (MR) is an emerging method that uses genetic variations as instrumental variables (IVs) to avoid confounders and reverse causality issues; it reveals causal relationships between exposure and a range of eyes disorders. Thus far, many MR studies have identified potentially causal associations between lifestyles or biological exposures and eye diseases, thus providing opportunities for further mechanistic research, and interventional development. However, MR results/data must be interpreted based on comprehensive evidence, whereas MR applications in ophthalmic epidemiology have some limitations worth exploring. Here, we review key principles, assumptions and MR methods, summarise contemporary evidence from MR studies on eye disease and provide new ideas uncovering aetiology in ophthalmology." @default.
• W4312218877 created "2023-01-04" @default.
• W4312218877 creator A5009590736 @default.
• W4312218877 creator A5017061461 @default.
• W4312218877 creator A5020147975 @default.
• W4312218877 creator A5022702196 @default.
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• W4312218877 creator A5042003426 @default.
• W4312218877 creator A5056979291 @default.
• W4312218877 creator A5071150248 @default.
• W4312218877 date "2022-12-26" @default.
• W4312218877 modified "2023-10-14" @default.
• W4312218877 title "Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data" @default.
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