Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312220102> ?p ?o ?g. }
- W4312220102 abstract "Although alterations in myeloid cells have been observed in COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine the function of classical CD14+ monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals. Monocytes from COVID-19 patients display altered expression of cell surface receptors and a dysfunctional metabolic profile that distinguish them from healthy monocytes. Secondary pathogen sensing ex vivo leads to defects in pro-inflammatory cytokine and type-I IFN production in moderate COVID-19 cases, together with defects in glycolysis. COVID-19 monocytes switch their gene expression profile from canonical innate immune to pro-thrombotic signatures and are functionally pro-thrombotic, both at baseline and following ex vivo stimulation with SARS-CoV-2. Transcriptionally, COVID-19 monocytes are characterized by enrichment of pathways involved in hemostasis, immunothrombosis, platelet aggregation and other accessory pathways to platelet activation and clot formation. These results identify a potential mechanism by which monocyte dysfunction may contribute to COVID-19 pathology." @default.
- W4312220102 created "2023-01-04" @default.
- W4312220102 creator A5002371270 @default.
- W4312220102 creator A5002409267 @default.
- W4312220102 creator A5008097907 @default.
- W4312220102 creator A5008779503 @default.
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- W4312220102 creator A5048140412 @default.
- W4312220102 creator A5048693285 @default.
- W4312220102 creator A5060012378 @default.
- W4312220102 creator A5072248402 @default.
- W4312220102 creator A5075835048 @default.
- W4312220102 creator A5078361796 @default.
- W4312220102 creator A5085724441 @default.
- W4312220102 creator A5089946818 @default.
- W4312220102 date "2022-12-26" @default.
- W4312220102 modified "2023-10-17" @default.
- W4312220102 title "Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19" @default.
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