Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312220331> ?p ?o ?g. }
- W4312220331 endingPage "343" @default.
- W4312220331 startingPage "331" @default.
- W4312220331 abstract "Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 (IL-6) superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid leukemia cells and thus inhibit their proliferation. Subsequent studies have highlighted the multi-functions of LIF under a wide variety of physiological and pathological conditions in a highly cell-, tissue-, and context-dependent manner. Emerging evidence has demonstrated that LIF plays an essential role in the stem cell niche, where it maintains the homeostasis and regeneration of multiple somatic tissues, including intestine, neuron, and muscle. Further, LIF exerts a crucial regulatory role in immunity and functions as a protective factor against many immunopathological diseases, such as infection, inflammatory bowel disease (IBD), and graft-verse-host disease (GVHD). It is worth noting that while LIF displays a tumor-suppressive function in leukemia, recent studies have highlighted the oncogenic role of LIF in many types of solid tumors, further demonstrating the complexities and context-dependent effects of LIF. In this review, we summarize the recent insights into the roles and mechanisms of LIF in stem cell homeostasis and regeneration, immunity, and cancer, and discuss the potential therapeutic options for human diseases by modulating LIF levels and functions." @default.
- W4312220331 created "2023-01-04" @default.
- W4312220331 creator A5017058735 @default.
- W4312220331 creator A5052713292 @default.
- W4312220331 creator A5066337255 @default.
- W4312220331 creator A5075260847 @default.
- W4312220331 creator A5078304350 @default.
- W4312220331 creator A5080125836 @default.
- W4312220331 creator A5090352464 @default.
- W4312220331 date "2023-02-01" @default.
- W4312220331 modified "2023-10-16" @default.
- W4312220331 title "Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases" @default.
- W4312220331 cites W1496710035 @default.
- W4312220331 cites W1509811505 @default.
- W4312220331 cites W1554341622 @default.
- W4312220331 cites W1557020267 @default.
- W4312220331 cites W1596258860 @default.
- W4312220331 cites W1607864895 @default.
- W4312220331 cites W171395049 @default.
- W4312220331 cites W1793068886 @default.
- W4312220331 cites W1824670638 @default.
- W4312220331 cites W1838662971 @default.
- W4312220331 cites W1897588476 @default.
- W4312220331 cites W1913053163 @default.
- W4312220331 cites W1942105196 @default.
- W4312220331 cites W1943460061 @default.
- W4312220331 cites W1964250163 @default.
- W4312220331 cites W1966315284 @default.
- W4312220331 cites W1968438837 @default.
- W4312220331 cites W1971620413 @default.
- W4312220331 cites W1975572622 @default.
- W4312220331 cites W1984437453 @default.
- W4312220331 cites W1985859986 @default.
- W4312220331 cites W1987443814 @default.
- W4312220331 cites W1988651625 @default.
- W4312220331 cites W1988875977 @default.
- W4312220331 cites W1990574061 @default.
- W4312220331 cites W1992160731 @default.
- W4312220331 cites W1995176683 @default.
- W4312220331 cites W1995375824 @default.
- W4312220331 cites W1995854660 @default.
- W4312220331 cites W1998832307 @default.
- W4312220331 cites W2000937423 @default.
- W4312220331 cites W2005332192 @default.
- W4312220331 cites W2009888091 @default.
- W4312220331 cites W2012416768 @default.
- W4312220331 cites W2012895108 @default.
- W4312220331 cites W2013801759 @default.
- W4312220331 cites W2014139160 @default.
- W4312220331 cites W2015041766 @default.
- W4312220331 cites W2020575974 @default.
- W4312220331 cites W2023599593 @default.
- W4312220331 cites W2024985051 @default.
- W4312220331 cites W2028682409 @default.
- W4312220331 cites W2029663217 @default.
- W4312220331 cites W2029669343 @default.
- W4312220331 cites W2031044887 @default.
- W4312220331 cites W2032519256 @default.
- W4312220331 cites W2032554944 @default.
- W4312220331 cites W2037840450 @default.
- W4312220331 cites W2039966688 @default.
- W4312220331 cites W2045546113 @default.
- W4312220331 cites W2050354476 @default.
- W4312220331 cites W2054225949 @default.
- W4312220331 cites W2054630119 @default.
- W4312220331 cites W2058415116 @default.
- W4312220331 cites W2060925085 @default.
- W4312220331 cites W2068461614 @default.
- W4312220331 cites W2073504771 @default.
- W4312220331 cites W2078918521 @default.
- W4312220331 cites W2081347853 @default.
- W4312220331 cites W2086221260 @default.
- W4312220331 cites W2088874236 @default.
- W4312220331 cites W2094111001 @default.
- W4312220331 cites W2096428863 @default.
- W4312220331 cites W2097259163 @default.
- W4312220331 cites W2101151845 @default.
- W4312220331 cites W2102486002 @default.
- W4312220331 cites W2113898952 @default.
- W4312220331 cites W2115437386 @default.
- W4312220331 cites W2115558627 @default.
- W4312220331 cites W2119174526 @default.
- W4312220331 cites W2127553277 @default.
- W4312220331 cites W2145472461 @default.
- W4312220331 cites W2151513770 @default.
- W4312220331 cites W2156696636 @default.
- W4312220331 cites W2161241282 @default.
- W4312220331 cites W2162530908 @default.
- W4312220331 cites W2162696517 @default.
- W4312220331 cites W2165176446 @default.
- W4312220331 cites W2167115799 @default.
- W4312220331 cites W2171423850 @default.
- W4312220331 cites W2173990401 @default.
- W4312220331 cites W2223535266 @default.
- W4312220331 cites W2287603172 @default.
- W4312220331 cites W2472915223 @default.
- W4312220331 cites W2617763968 @default.
- W4312220331 cites W2626842659 @default.