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- W4312222023 endingPage "121983" @default.
- W4312222023 startingPage "121983" @default.
- W4312222023 abstract "The basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix (ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial roles in regulating the unique physiological barrier function of the BBB, which represents a major obstacle for brain drug delivery. Owing to the difficulty in mimicking the unique biophysical and chemical features of BM in in vitro systems, current in vitro BBB models have suffered from poor physiological relevance. Here, we describe a highly ameliorated human BBB model accomplished by an ultra-thin ECM hydrogel-based engineered basement membrane (nEBM), which is supported by a sparse electrospun nanofiber scaffold that offers in vivo BM-like microenvironment to BMECs. BBB model reconstituted on a nEBM recapitulates the physical barrier function of the in vivo human BBB through ECM mechano-response to physiological relevant stiffness (∼500 kPa) and exhibits high efflux pump activity. These features of the proposed BBB model enable modelling of ischemic stroke, reproducing the dynamic changes of BBB, immune cell infiltration, and drug response. Therefore, the proposed BBB model represents a powerful tool for predicting the BBB permeation of drugs and developing therapeutic strategies for brain diseases." @default.
- W4312222023 created "2023-01-04" @default.
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- W4312222023 creator A5045433731 @default.
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- W4312222023 creator A5079746449 @default.
- W4312222023 date "2023-02-01" @default.
- W4312222023 modified "2023-10-17" @default.
- W4312222023 title "Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane" @default.
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- W4312222023 doi "https://doi.org/10.1016/j.biomaterials.2022.121983" @default.
- W4312222023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610323" @default.
- W4312222023 hasPublicationYear "2023" @default.
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