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• W4312222485 endingPage "321" @default.
• W4312222485 startingPage "307" @default.
• W4312222485 abstract "The emergence of a novel class of infectious agent composed exclusively of a misfolded protein (termed prions) has been a challenge in modern biomedicine. Despite similarities on the behavior of prions with respect to conventional pathogens, the many uncertainties regarding the biology and virulence of prions make them a worrisome paradigm. Since prions do not contain nucleic acids and rely on a very different way of replication and spreading, it was necessary to invent a novel technology to study them. In this article, we provide an overview of such a technology, termed protein misfolding cyclic amplification (PMCA), and summarize its many applications to detect prions and understand prion biology." @default.
• W4312222485 created "2023-01-04" @default.
• W4312222485 creator A5073918897 @default.
• W4312222485 creator A5085647135 @default.
• W4312222485 creator A5086529957 @default.
• W4312222485 date "2022-12-26" @default.
• W4312222485 modified "2023-10-17" @default.
• W4312222485 title "PMCA for ultrasensitive detection of prions and to study disease biology" @default.
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