FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312223097> ?p ?o ?g. }

• W4312223097 endingPage "449" @default.
• W4312223097 startingPage "449" @default.
• W4312223097 abstract "Regulated cell death (RCD) has a significant impact on development, tissue homeostasis, and the occurrence of various diseases. Among different forms of RCD, ferroptosis is considered as a type of reactive oxygen species (ROS)-dependent regulated necrosis. ROS can react with polyunsaturated fatty acids (PUFAs) of the lipid (L) membrane via the formation of a lipid radical L• and induce lipid peroxidation to form L-ROS. Ferroptosis is triggered by an imbalance between lipid hydroperoxide (LOOH) detoxification and iron-dependent L-ROS accumulation. Intracellular iron accumulation and lipid peroxidation are two central biochemical events leading to ferroptosis. Organelles, including mitochondria and lysosomes are involved in the regulation of iron metabolism and redox imbalance in ferroptosis. In this review, we will provide an overview of lipid peroxidation, as well as key components involved in the ferroptotic cascade. The main mechanism that reduces ROS is the redox ability of glutathione (GSH). GSH, a tripeptide that includes glutamic acid, cysteine, and glycine, acts as an antioxidant and is the substrate of glutathione peroxidase 4 (GPX4), which is then converted into oxidized glutathione (GSSG). Increasing the expression of GSH can inhibit ferroptosis. We highlight the role of the xc- GSH-GPX4 pathway as the main pathway to regulate ferroptosis. The system xc-, composed of subunit solute carrier family members (SLC7A11 and SLC3A2), mediates the exchange of cystine and glutamate across the plasma membrane to synthesize GSH. Accumulating evidence indicates that ferroptosis requires the autophagy machinery for its execution. Ferritinophagy is used to describe the removal of the major iron storage protein ferritin by the autophagy machinery. Nuclear receptor coactivator 4 (NCOA4) is a cytosolic autophagy receptor used to bind ferritin for subsequent degradation by ferritinophagy. During ferritinophagy, stored iron released becomes available for biosynthetic pathways. The dysfunctional ferroptotic response is implicated in a variety of pathological conditions. Ferroptosis inducers or inhibitors targeting redox- or iron metabolism-related proteins and signal transduction have been developed. The simultaneous detection of intracellular and extracellular markers may help diagnose and treat diseases related to ferroptotic damage." @default.
• W4312223097 created "2023-01-04" @default.
• W4312223097 creator A5013896318 @default.
• W4312223097 creator A5025170901 @default.
• W4312223097 creator A5032540752 @default.
• W4312223097 creator A5053757213 @default.
• W4312223097 creator A5064783426 @default.
• W4312223097 creator A5074647755 @default.
• W4312223097 date "2022-12-27" @default.
• W4312223097 modified "2023-10-01" @default.
• W4312223097 title "Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis" @default.
• W4312223097 cites W1798710600 @default.
• W4312223097 cites W1967828797 @default.
• W4312223097 cites W1981835390 @default.
• W4312223097 cites W1995160678 @default.
• W4312223097 cites W1996152690 @default.
• W4312223097 cites W1997183854 @default.
• W4312223097 cites W2004593104 @default.
• W4312223097 cites W2010802040 @default.
• W4312223097 cites W2014179433 @default.
• W4312223097 cites W2020866868 @default.
• W4312223097 cites W2025639892 @default.
• W4312223097 cites W2029564171 @default.
• W4312223097 cites W2035714184 @default.
• W4312223097 cites W2035898183 @default.
• W4312223097 cites W2042141743 @default.
• W4312223097 cites W2046898715 @default.
• W4312223097 cites W2047922328 @default.
• W4312223097 cites W2056338968 @default.
• W4312223097 cites W2058913657 @default.
• W4312223097 cites W2060035882 @default.
• W4312223097 cites W2063116304 @default.
• W4312223097 cites W2063919294 @default.
• W4312223097 cites W2067107606 @default.
• W4312223097 cites W2091960716 @default.
• W4312223097 cites W2093870248 @default.
• W4312223097 cites W2100671540 @default.
• W4312223097 cites W2112458084 @default.
• W4312223097 cites W2146558971 @default.
• W4312223097 cites W2158036091 @default.
• W4312223097 cites W2263341710 @default.
• W4312223097 cites W2275201610 @default.
• W4312223097 cites W2298261633 @default.
• W4312223097 cites W2414659015 @default.
• W4312223097 cites W2583594489 @default.
• W4312223097 cites W2592029987 @default.
• W4312223097 cites W2603130010 @default.
• W4312223097 cites W2740391009 @default.
• W4312223097 cites W2743915325 @default.
• W4312223097 cites W2762087180 @default.
• W4312223097 cites W2773289331 @default.
• W4312223097 cites W2803189841 @default.
• W4312223097 cites W2892710900 @default.
• W4312223097 cites W2905675459 @default.
• W4312223097 cites W2906319220 @default.
• W4312223097 cites W2909817598 @default.
• W4312223097 cites W2921575300 @default.
• W4312223097 cites W2943244321 @default.
• W4312223097 cites W2943793201 @default.
• W4312223097 cites W2945161487 @default.
• W4312223097 cites W2971048027 @default.
• W4312223097 cites W2980472864 @default.
• W4312223097 cites W2981179816 @default.
• W4312223097 cites W2984200309 @default.
• W4312223097 cites W2989385987 @default.
• W4312223097 cites W2997323331 @default.
• W4312223097 cites W3005104290 @default.
• W4312223097 cites W3006048658 @default.
• W4312223097 cites W3007726766 @default.
• W4312223097 cites W3011642937 @default.
• W4312223097 cites W3011868091 @default.
• W4312223097 cites W3012507702 @default.
• W4312223097 cites W3012782412 @default.
• W4312223097 cites W3012841328 @default.
• W4312223097 cites W3013314180 @default.
• W4312223097 cites W3016093449 @default.
• W4312223097 cites W3020890805 @default.
• W4312223097 cites W3026713315 @default.
• W4312223097 cites W3027169469 @default.
• W4312223097 cites W3090830154 @default.
• W4312223097 cites W3091175966 @default.
• W4312223097 cites W3092589524 @default.
• W4312223097 cites W3096036094 @default.
• W4312223097 cites W3096214704 @default.
• W4312223097 cites W3099300382 @default.
• W4312223097 cites W3108493784 @default.
• W4312223097 cites W3123756955 @default.
• W4312223097 cites W3123922203 @default.
• W4312223097 cites W3134883985 @default.
• W4312223097 cites W3159261210 @default.
• W4312223097 cites W3185682642 @default.
• W4312223097 cites W3192249208 @default.
• W4312223097 cites W3196924901 @default.
• W4312223097 cites W3197236939 @default.
• W4312223097 cites W3207848283 @default.
• W4312223097 cites W4200495237 @default.
• W4312223097 cites W4206163244 @default.
• W4312223097 cites W4223908131 @default.

• next