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- W4312234999 abstract "The scope of scientific literature was reviewed to summarize the data on the 223Radichloride therapy for castration resistant forms of prostate cancer. Key advantages of the alphaemitters over betaemitting radionuclides are highlighted in the treatment of hormoneresistant bone metastases. Data demonstrating an association between the 223Radichloride treatment effectiveness and absorbed therapeutic doses were analyzed. Dependence between the 223Ra and 18Ffluoride absorbed doses in bone metastases was evaluated, which should be taken into account in a positron emission tomography monitoring. Results of studies examining the uptake of 18Ffluoride to predict the 223Radichloride accumulation during the first course of treatment were analyzed. Research areas requiring further concern have been identified through the literature review, namely: study of the relationship between an absorbed dose and other clinically relevant endpoints, including pain index, changes in alkaline phosphatase or prostate antigen levels, survival rates, and development of alternative treatment regimens depending on the therapeutic radiopharmaceutical dose.Provedeno analiz naukovoï literatury z metoiu uzagal'nennia danykh shchodo radionuklidnoï terapiï kastratsiĭnorezystentnoï formy raku peredmikhurovoï zalozy z dopomogoiu 223Radykhlorydu. Vysvitleno osnovni perevagy al'faemiteriv pered betavyprominiuval'nymy radionuklidamy v likuvanni kistkovykh gormonorezystentnykh metastaziv. Proanalizovani roboty, v iakykh demonstruiet'sia zv'iazok mizh efektyvnistiu likuvannia 223Radykhlorydom i poglynutymy likuval'nymy dozamy. Takozh bula doslidzhena zalezhnist' mizh poglynutymy dozamy 223Ra i 18Fftorydu v kistkovykh metastazakh, shcho neobkhidno vrakhovuvaty pry provedenni monitoryngovoï pozytronnoemisiĭnoï tomografiï. Proanalizovani doslidzhennia, v iakykh vyvchalos' poglynannia 18Fftorydu dlia prognozu nakopychennia 223Radykhlorydu pid chas pershogo kursu likuvannia. Na osnovi analizu literaturnykh danykh vyznacheni napriamky, iaki potrebuiut' podal'shogo vyvchennia, a same: doslidzhennia zv'iazku mizh poglynutoiu dozoiu ta inshymy klinichno znachushchymy kintsevymy tochkamy, vkliuchaiuchy indeks boliu, zminy rivnia luzhnoï fosfatazy abo prostatychnogo antygenu, pokaznykiv vyzhyvanosti, a takozh, rozroblennia al'ternatyvnykh skhem likuvannia zalezhno vid dozy likuval'nogo radiofarmpreparatu." @default.
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- W4312234999 date "2022-01-01" @default.
- W4312234999 modified "2023-10-11" @default.
- W4312234999 title "RADIONUCLIDE THERAPY FOR BONE LESIONS IN CASTRATION-RESISTANT PROSTATE CANCER (STATE-OF-THE-ART LITERATURE REVIEW)" @default.
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- W4312234999 doi "https://doi.org/10.33145/2304-8336-2022-27-131-137" @default.
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