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- W4312238051 abstract "Knottins are small proteins, whose structure is determined by three disulfide bridges organized in an original pseudo-knot topology. Due to their unique properties, knottins provide a very promising scaffold for peptide-based drug development. Indeed, thanks to their small size, many knottin proteins may be obtained by chemical synthesis. Very stable, they present a high resistance to proteolysis due to the high density of the disulfide bridges and their compact pseudo-knot topology. Finally, this scaffold can carry a variety of functions and is very tolerant to sequence variations. In this chapter, we cover the history of knottin discovery, their nomenclature and classification, structural and physiochemical properties, and function. We also review recently commercialized knottin-based drugs and perspectives for future pharmacological development." @default.
- W4312238051 created "2023-01-04" @default.
- W4312238051 creator A5060243916 @default.
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- W4312238051 date "2022-01-01" @default.
- W4312238051 modified "2023-10-01" @default.
- W4312238051 title "Knottin peptidomimetics as therapeutics" @default.
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- W4312238051 doi "https://doi.org/10.1016/b978-0-12-820141-1.00019-4" @default.
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