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- W4312241200 abstract "Immunotherapy has reshaped the treatment landscape of head and neck cancer (HNC) in recent years, as it has become standard of care for advanced disease. Despite initial enthusiasm, currently approved agents targeting the programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immune-inhibitory axis offer clinical benefit in a small subset of patients, while prognosis of patients who relapsed is extremely poor. In this setting, investigators have focused on the role of alternative immune checkpoint molecules with the aim to overcome resistance and maximize immunotherapy benefit. Accumulating preclinical evidence have suggested a synergistic relationship among diverse immune checkpoints in HNC tumor microenvironment, thus paving the way for clinical studies to test the therapeutic efficacy of their combined inhibition." @default.
- W4312241200 created "2023-01-04" @default.
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- W4312241200 date "2022-01-01" @default.
- W4312241200 modified "2023-10-16" @default.
- W4312241200 title "Beyond PD-1/PD-L1 Immune Checkpoint Inhibitors: Other Targets and Approaches for Head and Neck Cancer" @default.
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- W4312241200 doi "https://doi.org/10.1007/13905_2022_30" @default.
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