Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312242006> ?p ?o ?g. }
- W4312242006 endingPage "316" @default.
- W4312242006 startingPage "308" @default.
- W4312242006 abstract "Pulmonary fibrosis is one of the commonest forms of interstitial lung diseases with poorly studied methods of its treatment in both human and veterinary medicines. Therefore, this paper focused on seeking alternative methods of its diagnostics and treatment. The article provides the results of the study of bronchoalveolar lavage fluid of rats with experimental lung fibrosis and influence of transplanted allogeneic mesenchymal stem cells of the bone marrow on stimulation of regenerative processes in damaged lung tissues. The studies were conducted on female Wistar rats with pulmonary fibrosis modeled using single transthoracic injection of solution of bleomycin hydrochloride. For the purpose of treatment, we used allogeneic mesenchymal stem cells introduced by various methods and the traditional treatment. We determined that best normalization of the parameters of the studied brochoalveolar lavage occurred in animals that received mesenchymal stem cells. The most active repair processes were in the experimental group that received the mesenchymal stem cells directly to the lung tissue. The animals that received intravenous injection of mesenchymal stemm cells were observed to have lower clinical parameters of the brochoalveolar lavage, but still better than such in the group treated traditionally. The lowest parameters were in animals that received the traditional treatment; they were greater than the phisological parameters, but significantly exceeded them in animals of the control group, indicating presence of inflammatory process in the lung tissue. The conducted cytological assays of the samples of the brochoalveolar lavage revealed that experimental animals with experimental pulmonary fibrosis had development of macrophage and lymphocytic reactions under the influence of transplanted mesenchymal stemm cells. We observed no atypical cells in all the experimental groups. This allows us to draw a conclusion that using stem cells by various methods of transplantation does not stimulate the onset of negative reactons (formation of atypical cells, metastatic processes, etc). Thus, the results of the study of the influence of transplanted mesenchymal stem cells demonstrate that in the conditions of experimental pulmonary fibrosis, the activity of regenerative processes in pathologically altered lung tissue may be an effective method of treatment of animals with this kind of pathology." @default.
- W4312242006 created "2023-01-04" @default.
- W4312242006 creator A5025489456 @default.
- W4312242006 creator A5067901480 @default.
- W4312242006 creator A5074316499 @default.
- W4312242006 date "2022-07-26" @default.
- W4312242006 modified "2023-10-18" @default.
- W4312242006 title "Effects of transplanted mesenchymal stem cells on repair of the lung tissue of rats with experimental pulmonary fibrosis" @default.
- W4312242006 cites W1510440645 @default.
- W4312242006 cites W1516256623 @default.
- W4312242006 cites W1845769873 @default.
- W4312242006 cites W1863614707 @default.
- W4312242006 cites W1980854324 @default.
- W4312242006 cites W1989338939 @default.
- W4312242006 cites W1990975603 @default.
- W4312242006 cites W1997082999 @default.
- W4312242006 cites W1999713206 @default.
- W4312242006 cites W2000229809 @default.
- W4312242006 cites W2001675896 @default.
- W4312242006 cites W2008253307 @default.
- W4312242006 cites W2020460921 @default.
- W4312242006 cites W2024793853 @default.
- W4312242006 cites W2030431346 @default.
- W4312242006 cites W2040111212 @default.
- W4312242006 cites W2041372926 @default.
- W4312242006 cites W2047310826 @default.
- W4312242006 cites W2049186779 @default.
- W4312242006 cites W2055289656 @default.
- W4312242006 cites W2060639938 @default.
- W4312242006 cites W2062073850 @default.
- W4312242006 cites W2068759261 @default.
- W4312242006 cites W2071904806 @default.
- W4312242006 cites W2072508023 @default.
- W4312242006 cites W2083653153 @default.
- W4312242006 cites W2085465728 @default.
- W4312242006 cites W2091526175 @default.
- W4312242006 cites W2100580906 @default.
- W4312242006 cites W2100646399 @default.
- W4312242006 cites W2101064515 @default.
- W4312242006 cites W2102782191 @default.
- W4312242006 cites W2103279664 @default.
- W4312242006 cites W2127100374 @default.
- W4312242006 cites W2127479534 @default.
- W4312242006 cites W2132967213 @default.
- W4312242006 cites W2135378032 @default.
- W4312242006 cites W2138946470 @default.
- W4312242006 cites W2139000046 @default.
- W4312242006 cites W2147156629 @default.
- W4312242006 cites W2148054347 @default.
- W4312242006 cites W2150103989 @default.
- W4312242006 cites W2155842880 @default.
- W4312242006 cites W2161006376 @default.
- W4312242006 cites W2165440991 @default.
- W4312242006 cites W2166672922 @default.
- W4312242006 cites W2171849700 @default.
- W4312242006 cites W2172089049 @default.
- W4312242006 cites W2233044846 @default.
- W4312242006 cites W2467708682 @default.
- W4312242006 cites W2468168745 @default.
- W4312242006 cites W2501527414 @default.
- W4312242006 cites W2528396128 @default.
- W4312242006 cites W2603921207 @default.
- W4312242006 cites W2756634427 @default.
- W4312242006 cites W2760372910 @default.
- W4312242006 cites W2761557216 @default.
- W4312242006 cites W2769010773 @default.
- W4312242006 cites W2789450435 @default.
- W4312242006 cites W2799479598 @default.
- W4312242006 cites W2800069852 @default.
- W4312242006 cites W2803543986 @default.
- W4312242006 cites W2889197569 @default.
- W4312242006 cites W2891255725 @default.
- W4312242006 cites W2906021714 @default.
- W4312242006 cites W2914342430 @default.
- W4312242006 cites W2943233832 @default.
- W4312242006 cites W2946059227 @default.
- W4312242006 cites W2954020470 @default.
- W4312242006 cites W2968261539 @default.
- W4312242006 cites W2997805831 @default.
- W4312242006 cites W3021543659 @default.
- W4312242006 cites W3025869828 @default.
- W4312242006 cites W3029278440 @default.
- W4312242006 cites W3035569755 @default.
- W4312242006 cites W3082740939 @default.
- W4312242006 cites W3103368740 @default.
- W4312242006 cites W3195179327 @default.
- W4312242006 cites W4229575383 @default.
- W4312242006 doi "https://doi.org/10.15421/022240" @default.
- W4312242006 hasPublicationYear "2022" @default.
- W4312242006 type Work @default.
- W4312242006 citedByCount "2" @default.
- W4312242006 countsByYear W43122420062023 @default.
- W4312242006 crossrefType "journal-article" @default.
- W4312242006 hasAuthorship W4312242006A5025489456 @default.
- W4312242006 hasAuthorship W4312242006A5067901480 @default.
- W4312242006 hasAuthorship W4312242006A5074316499 @default.
- W4312242006 hasConcept C126322002 @default.
- W4312242006 hasConcept C141071460 @default.